Niacin & butyric acid

[Discogs_discogs]

Does anyone here take niacin with butyric acid (or just one or the other). Do you feel confident that it has helped you or is it unclear?

[Gcf51]

check healthunlocked.com/cure-par...

[Missy0202]

I take a supplement called TRU NIAGEN. It contains 300 mg of Niagen™ (nicotinamide riboside chloride) providing 263 mg of nicotinamide riboside (NR) I can't comment whether I think it makes a difference or not because I am taking so many other supplements in conjunction.

[Lyricist]

Yes I take Butyrex (500mg x 3 morning and evening = 6 altogether ) and Niacin 600mg once per day. I think I maybe underusing them.

The research has recently been highlighted again by others on this forum (for which I thank them):-

1. Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease

pubmed.ncbi.nlm.nih.gov/333...

2. Niacin Ameliorates Neuro-Inflammation in Parkinson's Disease via GPR109A

pubmed.ncbi.nlm.nih.gov/315...

There are also many comments from forum participants if you search HealthUnlocked

However I cannot say whether these supplements are making a difference. I hope that they are doing, I do not experience (so far as I know) any of the problems set out in those papers but don’t know if I would have experienced those issues without these supplements.

It can’t do any harm now can it?

[Discogs_discogs in reply to Lyricist]

Lyricist, which brand new of niacin?

[parkylot in reply to Lyricist]

Our take

Generally safe

Prescription niacin might benefit people with high cholesterol who aren't able to take statins or haven't been able to control their cholesterol levels through use of a statin, diet and exercise. Don't take prescription niacin for high cholesterol if you're pregnant.

Safety and side effects

When taken orally in appropriate amounts, niacin appears to be safe.

High doses of niacin available via prescription can cause:

Severe skin flushing combined with dizziness

Rapid heartbeat

Itching

Nausea and vomiting

Abdominal pain

Diarrhea

Gout

Liver damage

Diabetes

Serious side effects are most likely if you take between 2,000 to 6,000 mg of niacin a day. If you think you might have overdosed on niacin, seek medical attention immediately.

If you have liver disease, peptic ulcer disease or severe low blood pressure (hypotension), don't take large amounts of niacin. The supplement has been linked with liver damage, can cause hypotension and might activate a peptic ulcer.

Taking niacin also might worsen allergies, gallbladder disease and symptoms of certain thyroid disorders. If you have diabetes, niacin can interfere with blood glucose control. Use niacin with caution if you have the complex form of arthritis gout. Niacin can cause an excess of uric acid in the blood (hyperuricemia), putting you at risk of gout.

If you're pregnant, don't take prescription niacin for high cholesterol. However, if needed to prevent or treat niacin deficiency, niacin is likely safe to take during pregnancy and in breast-feeding women when used in recommended amounts.

Interactions

Possible interactions include:

Alcohol. Taking niacin with alcohol might increase the risk of liver damage and worsen niacin side effects, such as flushing and itching.

Allopurinol (Zyloprim). If you're taking niacin and have gout, you might need to take more of this gout medicine to control your gout.

Anticoagulant and anti-platelet drugs, herbs and supplements. These types of drugs, herbs and supplements reduce blood clotting. Taking niacin with them might increase your risk of bleeding.

Blood pressure drugs, herbs and supplements. Niacin might have an additive effect when you take blood pressure drugs, herbs or supplements. This could increase your risk of low blood pressure (hypotension).

Chromium. Taking niacin with chromium might lower your blood sugar. If you have diabetes and take niacin and chromium, closely monitor your blood sugar levels.

Diabetes drugs. If you have diabetes, niacin can interfere with blood glucose control. You might need to adjust the dose of your diabetes drugs.

Hepatotoxic drugs, herbs and supplements. These drugs, herbs and supplements, like niacin, cause liver damage.

Statins. Research indicates that taking niacin with these cholesterol medications offers little additional benefit when compared with statins alone, and might increase the risk of side effects.

Zinc. Taking zinc with niacin might worsen niacin side effects, such as flushing and itching.

Mayo Clinic

[Lyricist in reply to parkylot]

I am grateful for that. I believe I read about all or most of those possible downsides when I first decided to take the combination of Niacin and Butyrex.But it is important that no one should take these or any other supplementary substances without being fully aware of any risks and only after weighing benefit against risk. I take a less cautious approach especially if something seems to provide benefit to me.

At present I hope I have the balance of prescription Co-car I dopa, Ropinirole, Rasagiline and supplements about right for me . But I am pragmatic and so I intend to look in detail at Bolt_Upright’s list of dopamine substitutes so that I am prepared when the prescription Dopamine no longer keeps me sane.

[Discogs_discogs]

... Nobody else uses this regimen?

[CaseyInsights in reply to Discogs_discogs]

My spouse takes 500mg of extended release Niacin along with 600mg Butyric Acid. I have recently added 500mg of TMG to this breakfast stack. This is the fist daily combo.

Works fine. The research is solid.

NAC - N-acetyl cysteine - should be part of the protocol. It protects the liver and is a key component in making glutathione - the body’s master antioxidant.

Weigh the risk and get off the fence 🌺

[Discogs_discogs in reply to CaseyInsights]

Thanks. Please tell us about the benefits of TMG for PD, ideally with reference to the scientific literature. Thank you!

[CaseyInsights in reply to Discogs_discogs]

The reference has been provided earlier in this thread. One contributor referenced it. See here for a full discussion 👇🏾

healthunlocked.com/cure-par...

[Lyricist]

I use Doctors Best 500mg

Photo of Niacin bottle

[Discogs_discogs in reply to Lyricist]

OK.... But doctor's best is not a flush-free type, is it? Does it have to be a sustained release type? I thought that type was harder on the liver. Also, did I do not read somewhere that nicotinamide or niacinamide were better? Thx

[Lyricist in reply to Discogs_discogs]

The type of Niacin I use is low flush not flush free. I am at an age when my quality of life involves choices between improving certain aspects of life at risk of adversely affecting others So to be frank I have put aside any worries about liver damage in the long term. I drink very little alcohol and lead a healthy life style. You will have to decide whether this is a risk to be taken or not. I believe, but cannot of course prove, that the combination of Butyrex and Niacin is improving my gut activity. Something is making me feel better. But it may be something else that is giving me this belief.. Sorry but I tend to make decisions based on “gut feelings” and this appealed to my gut.The other supplements may be better in specific circumstances so good luck.

[Gcf51]

I have some Butyrex ordered. But I brought some HBM at a local supplement shop, only has the calcium portion, but does seem to help.

[Gcf51]

What Is Butyric Acid, and Does It Have Health Benefits?

atlasbiomed.com/blog/what-i...