COMING SOON: Real PD Solutions (stay fit in the meantime)

[PDConscience]

With ISPCs producing new DA neurons, and diabetes type2 drugs stopping the death of DA neurons (and the progression of PD), research will soon converge at a real solution.

Your mission: Stay fit in the meantime.

youtu.be/8v1iVYIWLKw(Not working as expected?)

[jeffreyn]

Well said, PDConscience.

Here is some more information on the re-purposing of diabetes drugs.

scienceofparkinsons.com/201...

Here is some more information on induced pluripotent stem cells (IPSCs), and their (future) use in the treatment of PD (mainly). The video is a recent interview with Dr. Jeanne Loring of Scripps Research Institute (8th June 2018, approx. 30 mins).

facebook.com/ScrippsResearc...

[ConnieD]

Any idea how long before it comes to market?

[PDConscience in reply to ConnieD]

If you're referring to the implantation of DA neurons into the striatum of PD patients (to replace those lost), the first 10 human subjects - whose own 'autologous' IP stem cells have already been transcripted/differentiated as they await FDA approval for trial - is currently anticipated to take place early next year (2019). Larger multi-location studies are expected in subsequent trials.

[ConnieD in reply to PDConscience]

Yes thank you PDConscience!!

[francis6]

I asked the doctors at UCLH (where they have been trialling Exenatide) why, if they are pursuing success with T2 diabetes drugs, they are not recommending patients to follow regimes recommended for stabilising/reversing T2 diabetes? They shrugged. It would seem to me to be reasonable to follow a diet recommended for T2 diabetics (no sugar or refined carbs) as well as exercise.

[Kia17 in reply to francis6]

francis6

I totally agree with you. Most of the PwP have some sort of insulin resistance and adjustment to this issue could dramatically change the equation.

[francis6 in reply to Kia17]

Indeed. Seems to me that the doctors want to prescribe a pill when diet, exercise and good living in general could produce the same (if not better) results.

[Kia17 in reply to francis6]

That’s why ketogenic diet and exercise are the answers to the PD for now.

Fast walk would correct insulin sensitivity and over time it turns into a remedy for PwP.

IF WE Don’t Adjust our insulin sensitivity, NO PD medications or anti depressants in this world could help us.

For productions of Dopamine and seretonin , the insulin sensetivity is a MUST.

Once I shared this video. Please watch again:

youtu.be/Jq3GY27qWXM(Not working as expected?)

[francis6 in reply to Kia17]

Thanks very much for this. I have been on ketogenic diet for 4 months or so. First reason was because researchers in many countries are trialling T2 diabetes drugs with some early successes and, secondly, because my wife was diagnosed with T2 diabetes many years ago and wanted to give it a go. I am now on about 1/3rd the amount of Sinimet that I have been prescribed and my wife is now classified as "pre-diabetic" and has dropped her medication. It is little wonder given the unnaturally high amount of carbs in most diets. Trying a mix of exercise (swimming particularly good, it seems) and any sort of exercise seems beneficial.

Thanks again and good luck with your regime.