A clearly written article with many scientific words. Clues to PD symptoms subtypes.
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons.
Hiroyuki Sumikura, Masaki Takao, [...], and Shigeo Murayama.
Acta Neuropathol Commun. 2015; 3: 57.
Yes, there are many different types of Pd, but they all have one thing in common - they all have damaged brain cells in the substantia nigra. Please correct me if I am wrong.
To the very best of my knowledge, and I a not a scientist, the natural protein, GDNF, has been the only thing so far that has been shown to REPAIR THOSE DAMAGED NERVES! I am aware that some study tried to prove that GDNF is toxic in the brain, but that is a load of rubbish. Perhaps they meant that ARTIFICIAL GDNF is toxic in the brain.
Why are we dwelling on the differences in the various forms of Pd instead of concentrating on the ONE COMMON FACTOR?
Let us spend more money and time on finding a way to get the brain to produce MORE GDNF.
I have every reason to believe that this can be done, as it has happened to me! I know this is not good news for the drug companies but that is not our problem. We should all be interested only in looking for something that will help us either overcome many of the symptoms of Pd, as I have, or find a CURE, which is not in the interests of the drug companies.
Let us all contribute towards organizing a STUDY TO FIND THE BEST WAY TO INCREASE THE PRODUCTION OF GDNF IN OUR BRAIN!
HOW MUCH MORE SIMPLE CAN IT BE?
When patients start relying upon retired print shop operators to (mis)interpret science for them, to prescribe dubious solutions, and to propose nonsensical studies based upon naive and ill-founded conclusions (i.e., a single subjective, undocumented, unreplicated, entirely anecdotal case of "reversal" of "some of the symptoms") we're all doomed.
A couple Amazon reviews of JohnPepper's 2002 literary farce, 'Reverse Parkinson's Disease', accurately describe the fundamental problems with JP's credibility. Unless/until he is able to address these concerns, he has none (still waiting 15+ years after publication):
"Do NOT expect genuine 'reversal' by any contemporary sense of the word... The author has yet to provide credible evidence of both an actual Parkinson's diagnosis and - most importantly - whether he's actually accomplished anything beyond the general improvement of symptoms experienced by anyone who follows a regular program of vigorous exercise. The fact that - 15 years since original edition - not a single neurologist backs his claims of disease "reversal" should provide a clue: this book belongs in the 'fiction' section." 'W.D.'
Another review: "I do not doubt the sincerity of John Pepper and in the importance of exercise for people with Parkinsons. I do doubt his diagnosis as do some doctors, he freely admits this as well as describing his tremor as an action tremor not the resting tremor of Parkinsons and that sinemet made no difference to his symptoms. A positive response to sinemet is a common way to diagnose Parkinsons as opposed to other similar conditions. It is interesting that in all the years John Pepper has been advocating this method he cannot point to one person who has had the ongoing good results he claims..." 'rochfort'
Source: amazon.com/Reverse-Parkinso...
Underwhelmed by Madopar
Medication in hospitals, care homes or by carers.
I know vision is affected by by Parkinson's.
Parkinsons caused by sugar?
Madopar range by Roche
