Dr. Constantini in his latest email suggested to add acid folic to my dose of 2g/day of Thiamine HCL. So , last week, I added a pill of B6-B12 between the two B1 pills. But I noticed getting more agitated (the same happened when I raised the dose to 3g/day). I stopped the folic acid but still I was a little more shaky than usual.
Today in the morning I felt excellent; but I tried again folic acid between the two doses of Thiamine and after the second dose I felt very bad. I taught my heart would jump out of chest and I had the worst shaking. I drank lots of water to eliminate the Thiamine and in about 1 hour I calmed down. I do not know what folic acid does and why the dr. recommended it. Starting tomorrow I'll cut my dose to 1g/day and no more folic acid.
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Apparently, there is a difference between folic acid and folate. I've been reading recommendations to replace folic acid with folate and I've just bought some folate. I don't want to waste the folic acid so will alternate it with the folate! I'll Google to find out the difference.
Check out Ben Lynch, naturopath, who has done extensive research on MTHFR and recommends not to take folic acid because it really messes up your methylation. Best to stick with the the natural form of B9, folate.
As I said before B1 raises my blood pressure astronomically. I got up t o 3000 mg per day, I am now on only 500 milligrams per day. It's also raises my pulse rate. Benfotiamine also.
Is it possible to list any others supplements you do take? Do you have any other health condition such as high blood glucose levels or low/high levels of electrolytes?
If you take citicoline, you may reduce the dosage, or take a break off, as high levels of both Thiamine and citicoline in the brain act as a nootropic and elevate the acetylcholine levels in CNS and peripheral system; their synergistic effect may exacerbate agitation.
The fact is that HCL B1 has to be taken in big amounts, as it does not readily cross the brain barrier due to the structure of the molecule and its low bioavailability and as such may not be as efficient as other thiamine derivatives, which can be taken in much smaller quantities, such as Sulbutiamine, which was designed to reach the BB, and allithiamine, which is a true lipid soluble Thiamine.
Having big amounts of HCL Thiamine circulating in the blood, especially in the long term, may cause some adverse reactions or exacerbate existing health conditions, as high levels of Thiamine in the blood may compete with other vitamins and nutrients and eventually compromise the body balance.
When comes to PD and other neurological diseases, the bioavailability in the brain is what matters most and HCL Thiamine was never intended for such purpose. When comes to Thiamine HCL, it seems that there is not a single recipe for everyone. The same applies to Benfotiamine, which might have an even lower bioavailability in the brain, and as some studies suggest it may increase blood pressure in diabetic patients ncbi.nlm.nih.gov/pmc/articl...
Thank you for your reply. I am a diabetic 2, on small amounts of insulin. I still take citicoline but only 300 milligrams in the morning with my first C / l.
It makes sense what you say. I think both blood pressure and the pulse went crazy. Everything went very well till now and suddenly I had this problem. I'm not sure if the interaction Thiamine-acid folic created the issue or just the Thiamine. I'll make a break today and restart tomorrow in lower dose, probably 1g/day.
Go to drugs.com and you can check drug/vitamin/herb supplement interactions, and side effects of specific supplements, plus it will give you any drug out there that has potential for bad interaction with b1,6,12, folic acid.
Folate (natural) gets converted in the stomach. Folic acid (synthetic) has to go through the liver to get converted and can end up in the bloodstream, where you don't really want it to be.
Could also be the B12 if you have methylation issues. It can also push down potassium and cause heart palps. Had that myself in the past.
Treatment of mice with the NAD+ booster nicotinamide mononucleotide (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H2S), a DR mimetic and regulator of endothelial NAD+ levels. These findings have implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the elderly.
In the most exciting recent development in this area of research, Chinese nutritional scientists in Shanghai explored the combination of ALC with another energy-related nutrient, lipoic acid, in preventing PD-like changes in human neural cells in culture.70 They found that either nutrient, or the combination, applied for 4 weeks prior to a PD-inducing chemical, protected the cells from mitochondrial dysfunction, oxidative damage, and accumulation of the dangerous alpha-synuclein protein characteristic of PD.
Alpha Lipoic Acid supplement helps your body produce H2S, which presence helps to absorb greater amount of Niagen ( latest research from Harvard Univ. ). Also ala has many other benefits :
Ok everyone. Reading all above posts n wondering if anyone connects drinking coffee or their caffeine intake with the jittery feelings associated with the B1??
Or maybe taking the larger dose too fast as opposed to gradually increasing it. I am giving it to my bro n he felt jittery too. I’ve cut back on it (from 3000mg to 2000mg). He drinks 3 cups during the day
I’ve also been taking it n I also felt an increase heart rate. I cut bk n did it gradually n am now bk up to my initial intake of 1000mg. No caffeine for me
There is an easy way to test your hypothesis that caffeine from coffee in combination with high dose thiamine may cause jittery feelings: substitute 3 cups of decaf coffee for regular and see how you feel. Decaf coffee does have neuroprotective effect for PD:
Decaffeinated Coffee and Nicotine-Free Tobacco Provide Neuroprotection in Drosophila Models of Parkinson's Disease through an NRF2-Dependent Mechanism
Thank you. I’ll suggest it. He’s really attached to his coffee😩. I kindly referred to cause n affect this morning so we’ll see. He had reported increased dizziness. I don’t know if it’s his blood pressure pills or what. Thx again.
"Dear , stop taking B complex and folic acid for a week and let us know. Take 2grams/day thiamine each day."
It hope he does not try to use us like lab test mice. I'm still on 1g/day and I started being more cautions. I'll go to 1.5 and then 2. I felt ok for a month at 2g/day but now I'm concerned about some unknown side effects of hi doses of thiamine. I'm not sure yet the folic acid was the culprit.
Not to worry. I was 4g day for the longest. For two weeks, 6g day
Good for you! I take 3 grams of B1 daily, a multivitamin, and a large dose of Vitamin D. Nothing else. I think the B1 helps with energy and stiffness, but my symptoms are so mild it's hard to tell. I'm exercising hard 3 days a week. Hoping to be drug free as long as possible. I can't figure out why Costantini would lie. I have faith!
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Appropriate Thiamine dose when taking R Alpha Lipoic Acid
Book about thiamine for PD and other syndromes 
HYPERHOMOCYSTEINEMIA AND ITS TREATMENT IN PATIENTS WITH PARKINSON’S DISEASE 2016 (Treat it with folic acid?)
