Hello
I have early stages of PD , does anyone know whether CQ10 and vitamin e are beneficial ?
Thanks
Hello
I have early stages of PD , does anyone know whether CQ10 and vitamin e are beneficial ?
Thanks
Ubiquinol is said to be more effective. A new study found the combination of amega-3 and vitamin E to help in pwp.
Here are several cites (from among many) about PD ans CoQ10.
Randomized,
double-blind, placebo-controlled pilot trial of reduced coenzyme
Q10 for Parkinson's disease.
Parkinsonism
Relat Disord 2015 Aug;21(8):911-6.
ncbi.nlm.nih.gov/pubmed/260...
[In the abstract, methods and results merit attention.]
Does
high-dose coenzyme Q10 improve oxidative damage and clinical
outcomes in Parkinson's disease?
Antioxid
Redox Signal 2014 Jul 10;21(2):211-7.
ncbi.nlm.nih.gov/pubmed/244...
"Subjects with symptomatic benefits from CoQ10 (decrease in total
UPDRS >10 points) had lower baseline plasma ubiquinol (p=0.07,
Mann-Whitney U test) and decreased F2-isoprostanes per unit
arachidonate (p=0.04, Wilcoxon Signed-Ranks test). These results
lead to the hypothesis that the therapeutic response to CoQ10
depends on baseline levels of ubiquinol and whether the dosage of
CoQ10 used can ameliorate the burden of oxidative damage."
Coenzyme Q10
deficiency in patients with Parkinson's disease.
J
Neurol Sci 2012 Jul 15;318(1-2):72-5.
ncbi.nlm.nih.gov/pubmed/225...
"Compared to cases, PD patients had a significantly greater odds of
deficiency in coenzyme Q10 status (OR: 4.7-5.4; 95% CI: 1.5-17.7;
P=0.003-0.009) based on FIA results, but not of vitamin E, selenium,
lipoic acid, or glutathione (all P>0.05). The proportion of cases
with coenzyme Q10 deficiency was also significantly greater in cases
than in controls (32-36% vs. 8-9%; P=0.0012-0.006)."