Clinical Stabilization in Parkinson´s Disease: The Multi-Target Treatment Description and Results

[silvestrov]

Here is an interesting article entitled,

Clinical Stabilization in Parkinson´s Disease: The Multi-Target Treatment Description and Results

researchgate.net/publicatio...

[rebtar]

Wow! I've never heard of those substances. What do you think of this, Silvestrov?

[Boyce3600]

Thank you! I have been wondering where and how you are.

[silvestrov in reply to Boyce3600]

I am ok just worn out from working and finishing my doc. The day after I finished it the computer died and I had to resuscitate an old computer which too had died. I got lucky and made it work. I still habe some minor tweaks to do but it will wait until after my vacation next week.

Finally a break..

[Boyce3600 in reply to silvestrov]

Awwww what frustration. You sound like the type of person who handles that so well. Glad you're getting a break and a vacation. I would love to read the document. Breathe!

[silvestrov in reply to Boyce3600]

I rebound fast and am sure when I finally get away I will feel like the past struggles are gone and I will line up more projects (to get stressed about) in the future. Looking forward to time off.

[Alenaf]

Hmm, very interesting. I wonder if this substances converted to frequencies (using their molecular weights and a rife frequencies generator) are effective. Worth a try! Thank you, Silvestrov!

[glenandgerry in reply to Alenaf]

Hi Alenaf what do you know about Rife.....do you have a rife frequencies generator? I'm just beginning to look into it but there's a lot to learn.

[Alenaf in reply to glenandgerry]

Hi, glenandgerry,

I do have a spooky2 machine. It is relatively easy to use. plus there is a huge spooky2 comminity all over the world. Have been experimenting with the remote mode (the contact mode is next on my list as well as biofeedback). I think the darn thing is working! Haha!

[parkie13]

Except for the silymarin I haven't looked up any of the substances. Are they fairly easy to get? Any recommendation on them. Thank you for posting Mary

[faridaro]

I bought apigenin from Swanson vitamins before - time to start using it! Also, the humble celery contain apigenin and would be good to incorporate into the diet.

[Xenos]

Very interesting paper to says the least. Thank you so much Silvestrov.

So the magic formula would be :

- Ferulic acid 50 mg,

- Apigenin 100 mg,

- Gamma oryzanol (GO) 50 mg,

- Sylimarin 150 mg.

two times a day ?

Never heard of these substances before. They all seem to be widely used by naturopaths.

[hopeful88]

Silvestrov has the right idea. If you seriously want to slow the progression of PD, you're going to have to attack the multiple targets that are contributing to neurodegeneration. Doing this is going to require combinations of certain supplements, similar to what's shown in the study

[BUZZ1397]

Awesome anti-oxidants. Lets hope we can buy MTT compound otc soon.

[999---666 in reply to BUZZ1397]

worth a try.

[alexask]

From wikipedia

"en.wikipedia.org/wiki/Ferul...

Ferulic acid is found in the seeds of coffee, apple, artichoke, peanut, and orange, as well as in both seeds and cell walls of commelinid plants (such as rice, wheat, oats, the Chinese water chestnut (Eleocharis dulcis) and pineapple). Often in the form of chlorogenic acid.

In cereals, ferulic acid is localized in the bran the hard outer layer of grain. In wheat, phenolic compounds are mainly found in the form of insoluble bound ferulic acid and be relevant to resistance to wheat fungal diseases.[3] The highest known concentration of ferulic acid glucoside has been found in flax seed (4.1 ± 0.2 g/kg).[4] It is also found in barley grain.[5]"

So eat your apple cores, drink coffee and eat peanuts!

[alexask]

en.wikipedia.org/wiki/Apigenin

Apigenin is found in many fruits and vegetables, but parsley, celery, celeriac, and chamomile tea are the most common sources.[19] Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids.[16]

I am growing celeriac

I will be growing Chamomile next year.

[alexask]

Gamma oryzanol (GO) = Rice Bran Oil. Which is pretty cheap and widely available

[alexask]

"silymarin = Milk Thistle

Milk thistle, or Silybum marianum, is the richest source of silymarin. In fact, silymarin is often called milk thistle extract because its seeds contain about 70 percent of the phytonutrient according to the “Encyclopedia of Natural Medicine." Other parts of the milk thistle plant, such as the sprouts and stems, also contain silymarin, but the seeds are the most concentrated form. Milk thistle is indigenous to countries bordering the Mediterranean, where it is still thought of as a medicinal plant. In North America, milk thistle is often regarded as a weed and a target of pesticides. Silymarin is found in most plants of the thistle family.

Wild Artichokes

Wild artichokes are members of the thistle family and also contain decent amounts of silymarin. Silymarin accounts for the antioxidant behavior of artichokes and explains why it is food that can protect against the harmful effects of free radicals. Jerusalem artichokes do not contain silymarin because they are not members of the thistle family, despite their suggestive name.

Other Foods

Turmeric root and coriander seeds and leaves also contain silymarin. Turmeric is often ground into a yellow powder and used as a spice in curry dishes. Coriander leaves, also called cilantro, are a common additive in Thai and Mexican dishes. According to “Medical Herbalism” by David Hoffman, other foods that contain trace amounts of silymarin include dark-skinned grapes, beet greens, black cohosh, peanuts, brewer's yeast and most berries. Silymarin can also be consumed directly as an extract derived from milk thistle seeds."

So we know all about turmeric anyway. And brewers yeast - beer again.

[Astra7]

Can't seem to find out who wrote this paper and what their credentials are. I did note that this treatment is being patented however. I never quite trust science when there is money involved.

[silvestrov]

Here is the scientific citation:

Citation: Enrique de Font-Réaulx, et al. (2014) Clinical Stabilization in Parkinson´s Disease: The Multi-Target Treatment Description and Results. J Neurophysiol Neurol Disord 3: 1-7

The lead author is, Enrique de Font-Réaulx and he is Mexican. This explains the multiple misspellings of silymarin. Here is the man behind the study:

google.com/search?q=Enrique...

Also, ferulic acid can be purchased online in the form of Trans-ferulic acid:

exercise.com/supplements/tr...

Here is the OTC supplement:

sourcenaturals.com/products...

[laglag]

I have been taking "Protandim" for approximately 5 years. These are the ingredients:

1. Milk Thistle extract 225 mg containing 80% silymarin

2. Bacopa extract 150 mg containing 45% bacosides

3. Aswagandha root powder 150 mg

4. Green tea extract 75 mg containing 98% polyphenols

5. Tumeric extract 75 mg containing 95% curcumin

Here is a website about Protandim: protandim.com/what-is-prota...

Some think the company is making false claims that it can help certain ailments. Like all dietary supplements, it has not been evaluated by the FDA. It hasn't taken away and of my symptoms directly, but I can tell a difference in the severity if I quit taking it for a couple of weeks.

[999---666]

did you hear about new imaging machine that produces high definition view of axions? can see lesions on brain wiring. on bbc.

I've also read that high blood pressure can deprive brain of blood. yet they don't check carotids....a nobrainer it seems to me...if your brain isn't getting oxygen you don't have benefit of immune system, nutrients, what else? vascular disease, this movement disorder me thinks.

we all know what happens to a compost pile that doesn't get oxygen, eh?neurosciencenews.com/dement...

[sunvox]

Un-frickin' believable. Did you read that study? 99% of the participants stayed the same or got worse.

-

We included 40 patients with PD. Age: 32 to 90 years (mean 62 years, SD +/- 14.3), 23 female (57.5%), 17 male (42.5%). Initial UPDRS-3 score: 1-15 (mean 5, SD +/- 2.5). Maximum follow-up period: 84 months, mean 38 months (SD +/- 24.5). During the follow up period, 7 patients (17.5 %) improved their basal UPDRS-3 score while there was no change in score for 37 pa-tients (92.5 %). ere were 2 clinical remissions (5 %). e UP-DRS-3 was worse in 3 patients (7.5 %). Of these three patients, one discontinued the MTT for 18 months and deteriorated in that time. e mean UPDRS-3 score was 3 at 51 months of follow-up. Adverse eects: None.