Parkinsons starts in the gut

[rhyspeace12]

How many of you had constipation early on? My PD husband did.

sciencealert.com/scientists...

[Xenos]

You may have a look here :

caltech.edu/news/parkinsons...

There's likely something decisive there.

A few years ago, some people have been serendipitously cured from their PD symptoms when treated for Clostridium Difficile with heavy antibiotics. It took place in Sydney, Australia, with Dr Thomas Borody, a gastroenterologist.

AFAIK, they are now experimenting Fecal Transplantation.

[mblongdon]

I have wondered about this. I have been constipated most of my life. I shake much harder when I have a difficult BM. Makes me think there is a connection.

[Blackfeather]

Here is more info on the gut/brain axis and PD

nature.com/articles/s41531-...

[Mrswolf]

Hello,

I am new to this world of electronic connection as I am a private person. But I find myself changing with my newly "diagnosed" PD. Like many others whose posts I have read, the "diagnosis" is a circular reasoning that if the Sinemet works then I have PD; not the result of a test for PD.

I am deeply interested in this proposition that the symptoms I have that have lead a neurologist to the diagnosis are actually a result of intestinal inflammation. I have noticed for the past 2 years my symptoms are much worse just before I move my bowels. So much so that even the Sinemet doesn't affect them; especially the tremors.

Does anyone on this site know where to go. . . online or an actual doctor's office. . . to investigate this course of treatment or this connection?

[rhyspeace12]

This is interesting to me, obviously, since I posted the original information that my daughter sent to me. I have another daughter who has suffered a lot of IBS, constipation and so forth. I am now curious as to if it is a harbinger of PD, and if antibiotics would help her before she actually has the mount of inflammation that would cause PD.

[silvestrov in reply to rhyspeace12]

You may want to look into sodium butyrate for IBS:

ncbi.nlm.nih.gov/pubmed/227...

I have a friend who has IBS and have been looking into possible therapies for her. Interestingly IBS is more prevenant in women and it is because of estrogen. Male to female transsexuals have a greater frequency of IBS than men and female to male transsexuals have a lower prevalence of IBS than women. The difference is the former receives estrogen therapy and the latter, testosterone therapy. In women IBS symptoms decline with age. For PD patients sodium butyrate is neuroprotective:

ncbi.nlm.nih.gov/pubmed/236...

PS, Does she have mlgraines?

medscape.com/viewarticle/85...

Also, sodium butyrate should be taken with riboflavin:

google.com/patents/US4721716

Riboflavin appears to be good for PD:

scielo.br/scielo.phmoop?scr...

Riboflavin in good for migraines:

ncbi.nlm.nih.gov/pubmed/152...

[Hidden]

I experienced an infection in one leg that I believe was facilitated by sores caused by an allergy to my medication. The bacterial infection went viral (hahahaha thats a good one oh sorry) anyway the bacterial infection resulted in a leg saving surgery and through out I was on an antibacterial pump. The intravenous antibacterial lasted for about 8 weeks. Followed by pill forms of the same stuff.

The PD went away.

I searched the internet and found that there is a bacteria that lives commonly in our gut that is said to inhibit the uptake of the PD medication. I may have killed that bacteria. We cut down the amount of meds I was taking due to signs of over medication.

Two years later

I am back to where I was before the infection.

[Mrswolf in reply to Hidden]

Hello Gym Bag,

Can you please tell me which antibacterial was used? Thanks.

[Hidden in reply to Mrswolf]

No I am unable , initially the Doctors said that they had 3 big nucs of antibacterials and that one of them would do the job. One week later they were scrambling and it was not just the chance of loosing a leg any more. Experts consulted and a "soup" was made. They say that they got it but I am not so sure and if anything worked it was probably because I was on antibacterials a very,very long time . I think 12 weeks total the first time and a few weeks sometime later. Nurses came to the house to help change bandages for over a year. All during that time of recuperation the PD was much reduced ,but I could not take advantage of it and bowl problems wee a nightmare. It seemed like the better my legs got the worse the PD got until the PD came back with a vengeance. I can tell you what the follow up antibac was but not the one that stopped the progression. My Doctors and Neuro had no interest in my story and just smiled knowingly and ignored it . They get a lot of nuts like me, I guess . It was as if I had been wearing a hat made from aluminum foil.

[nelo23 in reply to Hidden]

I am also very interested in the antibacterial that was used.

I have been taking pro-biotics for years. I am 68 years old and have only taken one anti-biotic in my life. I have had problems with constipation for 30 years.

Maybe I have a bacteria that I need to get rid of.

[Beverly2017 in reply to Hidden]

Did your PD leave for good or is it back?

[Hidden in reply to Beverly2017]

oh it is back and worse much worse

The rate of change has gotten faster , the adventure continues.

[Beverly2017 in reply to Hidden]

Try lots of exercise and get your heart rate up. Everyday and don't give up. I take LDN. I think it helps

[Hikoi]

PARKINSON'S MOVEMENT

WEBINAR 4

GUT FEELINGS

4 years ago -

What does a movement disorder have to do with the gut you might ask. And, until recently, neurologists asked the same question. What is the link between the intestinal neurotransmitter systems and the basal ganglia in the brain? Can gut function tell us something about dopamine levels in the brain? Why does gut function mirror the brain? And most importantly, is the gut an early warning system for the brain? Can simple tests of gut function predict Parkinson's ahead of motor symptoms?

More here

healthunlocked.com/parkinso...

[Catlou]

I just had to post this:

drdavidwilliams.com/how-to-...

[rhyspeace12]

Mine Parky husband had constipation from the time he was a kid.

[Rosenmu]

I've been trying to build up the gut, detox the body and gut. My research shows toxins have adhered to the proteins causing them to fold wrong and then sent to the brain.