Neurogenesis

[metacognito]

Will we soon "harness the mechanism" for neurogenesis to repair neuronal deficiencies? A note of optimism: ed.ted.com/lessons/could-yo...

[BillDavid]

Thanks for the connection to TED-ed. If interested in Paradigm shown...Google "Forced Exercises". BillDavid

[metacognito in reply to BillDavid]

Yes, it all seems to get back to the proven benefits of those neurotrophic proteins - brain and glial-derived neurothrophic factors (BDNF/GDNF) - kicked off by EXERCISE as the best way currently available to regenerate a few neurons and slow the progression of PD symptoms.

[zawy]

Those who have track of my posts know how hard I've investigated nutrients. The benefits I received from 2 hours per day with my heart rate averaging 120 bpm (swimming and stationary bike) seem to blow everything else away, and even gave me the strong impression PD is partially reversible and completely stoppable, at least in my case. Also when I start talking to someone, a lot of things seem to immediately disappear, although soon returns as soon as I stop talking and get on the computer.

[etterus]

Excellent info.... Neuro plasticity enhanced by exercise is certainly the best we can do for ourselves today, but the future looks like that there will be an exciting breakthrough

[Hikoi]

Metacognito

Interesting ted talk thanks. Now here is another quite different but also on neuro genesis you may enjoy.

youtu.be/NT_Z6kULoVw(Not working as expected?)

[metacognito]

Hah! The human brain is the "Rolls Royce" of brains (gotta get mine in for a major tune-up Great presentation by a brilliant guy - thanks a lot for sending.

I'm currently reading an excellent book on the topic that covers aspects of diet & lifestyle most conducive to neurogenesis... something us PD folks want to pay attention to: amazon.com/Neurogenesis-Die...

[partypants in reply to metacognito]

Is this book worth reading metacognito ? My missus has already read lots of brain-related diet books (mainly by Dr Perlmutter etc). So I'm on a gluten free, low sugar/carb, high fat diet. I'm kind of assuming it's recommending a similar diet ?

[metacognito]

In my opinion, it IS a worthwhile read. It covers areas only touched upon in Perlmutter's ''Grain Brain' in terms of lifestyle adjustments. Together with diet and supplement recommendations (complete with explanations how/why they work), the author cites recent studies that demonstrate the neuron producing capacity of living in an "enriched environment" - or the human equivalent of running wheels, mazes, new/varied activities, etc. He also cites a recent Buck Institute for Research/UCLA study (published in the journal 'Aging' October 2014) that claims "the first known success for reversing Alzheimers' disease" using a simplified version of the diet/lifestyle strategies outlined in his book.

[Hikoi in reply to metacognito]

You are a critic of shaman type cures but follow Perlmutter and his work?

nymag.com/scienceofus/2015/...

[zawy in reply to Hikoi]

The article points out good reasons to be skeptical of him, but it is wrong to cite the "quackwatch" website as a legitimate source, especially in criticizing The Journal of Appl Nutrition. Each article in any journal should stand on its own merits, including higher skepticism when profits are the reason for the research.

There is a connection between gluten and Parkinson's, but not a lot of research. Only 12 articles show up in pubmed:

ncbi.nlm.nih.gov/pubmed/?te...

The PARK7 gene expression is increased in the presence of gluten sensitivity. Two of the articles were about that. PD is known to often begin in the GI tract.

Asian and American indian genes are more likely to be sensitive, since bread as a stable began "only" 5,000 to 10,000 years ago in the middle east, after the paleolithic era. For comparison, we all have genes from a single man who lived about 50,000 years ago and a woman who lived 200,000 years ago.

If not eating wheat makes you feel better and especially if gas and GI trouble are reduced, then by all means be a shaman and instead eat more canola oil (can be found in some mayonnaise, which I accidentally noticed made me feel better while visiting my mother). I recently found out there are not any articles supporting coconut oil for PD. It seems "Ray Peat" is spreading a lot of nonsense about it. Canola oil has the highest omega 3's except for flaxseed oil, and it turns out this is very important in PD. Olive oil does not have the omega 3's. There is a question mark concerning the DHA in fish oil and PD, which has a lot of omega threes.

So yes metacognito, join the shaman and avoid the gluten if you want by eating more canola oil. There were not any articles on canola directly, but it has the highest omega 3s in common oils, and there were 50 articles published on these and PD in the past 5 years.

[Hikoi in reply to zawy]

Zawy

You are doing a lot of research but I worry that you make a number of claims as fact when I think they are your belief or opinion. For example how do you know there is a connection between Parkinsons and gluten? Has that been proven, because as you write there is not much research on it. (I could find only 3 studies in pubmed).

[zawy in reply to Hikoi]

I see this web site mutated my link so you were not able to do the same search I did. Do a search on "Parkinson's gluten" at pubmed to see if you think my wording "a connection" is not the correct word. Searches on PD at pubmed need to include the apostrophe, but it seems this web site's programming messes that up.

[metacognito]

So... you would equate the work of David Perlmutter M.D. (whose work is based on methodical research and the latest studies in the field of neurology) with the likes of Shaman Zawy (whose work is based on his latest kitchen experiment with yesterday's leftovers)? I'm sure Shaman Zawy will be ecstatic to find that he has such an ardent fan of his "work".

In any case, most people who've bothered to crack a book understand the way science advances. Leaders in a given field or discipline extrapolate data and present their theories while others, in turn, then dissect the referred theories and critique the conclusions. I consider (or I "follow" if you prefer) the opinions and conclusions of both proponents and naysayers when devising my own little action plan as I await theory to become fact.

Unlike you, Zawy, and fellow members of the Flat Earther Social Club, however, I have little time or tolerance for the inevitable quacks and shamans who impulsively pop up with their nonsensical potions, lotions, and pills to entice the more malleable dupes among us.

I am hoping, nevertheless, that the famous "1 part bread with 2 parts mayonnaise" formula from Zawy's Magical Kitchen cures all your ills and that you're feeling 10-20 years younger by now (even if it is all transpiring in a compromised neural network). Cheers, M.

[Hikoi in reply to metacognito]

You did not read beyond the beginning of the article then? The shaman reference was to......

"Perlmutter co-wrote Power Up Your Brain with a “medical anthropologist and shaman” named Alberto Villoldo. The book opens with the tale of a woman suffering from chronic progressive multiple sclerosis, who, one afternoon, suddenly recovers and begins walking unassisted. “We are putting you on our miracle list,” Perlmutter tells her,......According to Perlmutter, open-minded healers like himself and the shaman are capable of achieving miraculous results that traditional doctors cannot. "

.".....Up until late last year, Perlmutter offered a “6-day Power Up Your Brain Personal Intensive Program” on Powerupyourbrain.com. The most expensive package cost $8,500 (that is, a touch under $1,500 per day), and it was designed to “cleanse your body” and “detox your brain” using “neuro-nutrients, hyperbaric oxygen treatments under medical supervision, and ancient energy medicine practices.” In addition to being granted access to “shamanic sessions” — the administration of which was taken over from Albert Villoldo by Perlmutter’s wife, Leize — participants received ......"

[metacognito]

Yup, I read it/caught your point. Science evolves, however, and opinions/knowledge evolve along with it.

You should not ignore the fact that the author of your expose' on Perlmutter is a professor of religion who is currently hustling to sell his own book, 'The Gluten Lie'. What better way to promote a new book than to critique the most visible proponent of the alternative view?

His book-selling tactics don't seem to be working too well however. When you compare their respective reviews and the stature of their respective supporters, the author (Alan Levinovitz) falls well short of Perlmutter. Of course it's up to you as to who YOU find more credible...

[Hikoi in reply to metacognito]

Hmm beginning to sound like you decide credibitility on personal bias as much as anyone else.

I haven't a clue who their respective supporters are.

[metacognito]

At last! A hint of functional neural activity... Yes, that tends to be the way the world works - a person's or an institution's credibility tends to be subjective to the person doing the evaluating - bravo!

I, for example, certainly don't defer to a shitwit from the Flat Earther Social Club when evaluating the work/credibility of a given researcher or author.

In determining who's more credible between Perlmutter (who among his various awards counts the Linus Pauling Award for his work with NEUROLOGICAL DISORDERS... and whose latest book is currently no. 1 on Amazon), or your hero Alan Levinovitz (an assistant professor at a mediocre university whose "academic work focuses on classical Chinese thought, the philosophy of play, and the intersection of religion and medicine"... and whose latest book is currently ranked no. 76, 550), your suggestion that I pay heed to Levinovitz fails to persuade.