My nephew has been diagnosed with CMT1A ( PMP22 and LRSAM1) - his mum and dad have been tested and my nephew has inherited the PMP 22 (dominant gene) from his dad (my brother) and the LRSAM1 (recessive gene) from his mum. Although my brother seems ok, they think he may be affected. I find all this very difficult to understand and apologies if I have got anything wrong here. My brother sent me all the relevant documents but it's not easy to get my head round it! I'm wondering if I should get tested (I'm 67). I have a son and daughter and my daughter has three children. I'm not too concerned about myself but I am concerned about my children and grandchildren. They all seem fine, but I understand the effects of this can make themselves known anytime between 5 and 25. Can anyone give me some advice?