A new Study: Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) (SUPERNOVA)

[Jm954]

The aim of this worldwide study is to assess the safety and neutralizing activity of AZD5156 for prevention of COVID-19 in immunocompromised individuals compared to AZD7442 (EVUSHELD) in 3200 immunocompromised adults and adolescents 12 years of age or older (weighing at least 40 kg) in approximately 20 countries.

There are four sites in the UK, one in Manchester, two in London and another in Nottingham. Only the Manchester site is taking enquiries at the moment from patients wanting to participate. The contact details are as follows: Alison Uriel Email: [e-mail]. Address: Delaunays Rd, Crumpsall, Manchester M8 5RB, United Kingdom Phone: [phone]

A full list of sites and more details regarding inclusion and exclusion criteria on the link here:

clinicaltrials.gov/ct2/show...

Jackie

[mrsjsmith]

Thank you Jackie I had heard something about this.

Am I being dim but I can’t see which are the London hospitals listed, but worked out that IVIG excludes me from the first phase, so I wonder when the third phase will recruit ?

Colette

[Jm954 Administrator in reply to mrsjsmith]

Unfortunately, I think your ivig treatment will exclude you from any trial as you probably have some passive immunity from that. The London hospitals weren't listed were they?

[mrsjsmith in reply to Jm954]

Thanks Jackie,

I could only see IVIG excluded in phase 1 but no mention of it for phase 3 !

Somewhere else a friend and fellow patient found the London post codes and thinks they are St Thomas and UCLH, so perhaps useful for any London members that meet the criteria to look out for updates.

Colette

[skipro]

thx

I do not see any sites listed for the USA.

Do you know any will come available

Thx

Skipro

[Jm954 Administrator in reply to skipro]

This is all that I know I'm afraid.

[KrisBren01]

Hi Jackie, I've emailed regarding this just waiting for a response from them. Probably be a while as many emails are going to be sent. Will let you know how I get on and if I get any further information. Thanks Sue xx

[annmcgowan]

Hi Jackie thank you for this post. It looks like my age over 55 and the fact I am on Ibrutinib will exclude me at least from the first phase if I have read this correctly?

Ann

[bennevisplace in reply to annmcgowan]

Jackie will correct me if I'm wrong, but I think the idea of the small phase 1 trial in healthy volunteers is to establish the safety profile of the new drug before it's unleashed on the 3,200 immune-compromised subjects in the main (phase 3) trial. So I don't expect the latter trial to get going for a few months yet, and that's the one you want to be in, as you stand a 50/50 chance of getting Evusheld Mk1 / Mk2.

[annmcgowan in reply to bennevisplace]

Hi thank you for your reply I am sure you are correct. Role on later phases.

Take care

Ann