Just found about it, does anybody tried it ? nature.com/articles/bcj201474
Neem extract nimbolide: Just found about it... - CLL Support
Neem extract nimbolide
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Pvasile
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AussieNeilAdministrator
To add some context to these studies, the second, much more recent paper, "A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL" can be ignored, as it's about Chronic Myeloid Leukaemia, which arises in the myeloid stem cell line, not the lymphoid stem cell line and there are different cellular pathways involved. That's why we don't read about targeted protein degradation (TPD) and proteolysis-targeting chimeras in successful CLL therapies.
The first paper "Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia" from late 2014 is more interesting, given Waldenströms macroglobulinemia (WM) is a Non-Hodgkin’s lymphoma, reasonably closely related to CLL and with which we share some treatment drugs in common - and there's the rub, as I'll explain later. Some other B cell blood cancer cell lines were also used in the study, but of note, it's hard to establish CLL cell lines, because CLL cells do die naturally from apoptosis, it just takes longer than they take to clone, so they accumulate.
The paper sets the scene with "Over the last three decades ~70% of the Food and Drug Administration approved drugs have been developed from natural sources.9 Naturally occurring compounds remain a critical reservoir for drug development."Thereby introducing "Nimbolide is a potent limonoid triterpene that is derived from the neem plant." (my emphasis).
Given the above, you would expect some further research, yet all I could find, was this seemingly encouraging paper on CLL, but it's also from 2014 . 
Neem leaf extract induces cell death by apoptosis and autophagy in B-chronic lymphocytic leukemia cells
tandfonline.com/doi/abs/10....
That concluded, after an microscopic observation of what happened to CLL cells taken from patients and exposed to a Neem leaf extract in dish; "NLE exhibits anti-leukemic properties in patient primary CLL cells and demonstrates clinical efficacy, warranting further investigation as a potential therapy for CLL".
While it appears from the above that nimbolide might be useful in synergistic use to treat B cell cancers, I couldn't find any further research after 2014 and 8 years is a long time in CLL treatment advances. Since 2014, we've had acalabrutinib, ibrutinib and venetoclax approved for the treatment of CLL. Those with WM have had ibrutinib and zanubrutinib approved and there are venetoclax clinical trials in progress.
We last discussed this 3 years ago and you can read the conclusions here:
healthunlocked.com/cllsuppo...
Neil
Thank you very much for this valuable information. It's my understanding that it's extremely difficult to fund research on "natural" substances, such as neem, because a product based on natural substances cannot be patented and therefore would not be profitable. Could that explain why there has been no more research on neem since the promising research in 2014?
Related to this, I recently started taking 50 mg of zinc daily and found it eliminated my tendency to mouth and ear infections (due to CLL). I then stumbled on MANY journal articles linking good blood zinc levels to good cancer prognosis (including leukemia). I attribute the absence of this info from billboards to the same reason why there's been no more research on neem.
As the article about Nimbolide says, "Over the last three decades ~70% of the Foodland Drug Administration approved drugs have been developed from natural sources." That wouldn't happen if there was no reward for doing so! You can profit by patenting a way to harvest a natural substance, how to derive a purified extract of the active ingredient used to fight cancer, or by describing the packaging process for optimal absorption or by describing how to apply the plant to treat cancer and so on. Here's some patents for the use of the Neem plant to treat cancer:-
WO2015035199A1 - Neem compositions used for the treatment of cancer
patents.google.com/patent/W...
Nimbolide analogs as anti-cancer agents and preparation thereof
patents.google.com/patent/U...
So that can't be reason for the lack of research, unless suppliers are charging too much and that doesn't seem to be the case, given the supplement advertising!
There are also patents for zinc! For example
Stable composition of vitamin c and zinc tablet
patents.google.com/patent/W...
Other examples I know of:-
- The process Misui Norin use for making the pharmaceutical grade Polyphenon E, EGCG extract from green tea used by Mayo Clinic in the phase 1 and 2 clinical trials is protected by patents in Europe and the United States.
- Mayo Clinic patented the use of EGCG from green tea in synergistic use with proven CLL and other blood cancer drugs. There are three patents if I recall correctly.
You can also see these patents on-line!
You can also most certainly patent a cultivar which has been bred to produce a higher quantity of the active ingredient or you can establish a trade mark! See Plant Breeders Rights and other IP rights: ipaustralia.gov.au/plant-br...
So I think we can safely discard the argument that the inability to patent the use of natural substances is why they aren't used for cancer treatments.
Neil
Thank you very much. When I read the article closely, I saw and was surprised about the quote you mention at the start of this reply! Apparently I've been using the red herring Seymour B mentions in the following reply. Thanks again.
LadyLuckyLuna -
I think it's actually quite easy to find studies of natural products, because so many other countries have different medical traditions, and need to keep treatment costs down. I think the patent issue is a common red herring. There are 1668 papers mentioning Neem available on PubMed:
pubmed.ncbi.nlm.nih.gov/?te...
But the presence of a paper there does not mean that it's a quality study. Even Harvard, Stanford, and Oxford have retractions after criticism.
The things to look for in studies of natural substances are:
Is it an in-vitro test? In-vitro results seldom are reproducible in-vivo. One simply cannot move from an in-vitro test to oral medication. Often, the effective in-vitro dose is simply not achievable orally because of digestion and metabolism. Many natural products in raw form have many other natural chemicals than the ones isolated in-vitro. The additional natural chemicals in the product can be a problem.
Was it an extract from a natural substance? How was the extract prepared? Extracts can be highly concentrated, and can eliminate possible toxic ingredients. One can extract multiple separate chemicals from a natural substance. We can't generalize safety or effectiveness from an extract to the raw substance.
What was the dose? Low quality studies do not mention dosage, or fail to note the source of the product.
How does one shop for products to duplicate that dosage? I suggest subscribing to consumerlabs.com, which tests many natural products for dosage and contaminants, and also has links to studies.
What are the toxicities of the natural substance? We simply cannot assume that natural=safe. Many poisons are natural. Many substances are safe in low dosages that are not safe at higher levels that might be effective. Many studies provide no toxicity information.
Look for RCT - Randomized Controlled Trials. These can be gamed on purpose, but it's harder. They can also be flawed by not controlling for confounding factors, such as properly matching age, sex, and comorbidities. They might use a small, easily chosen population that doesn't match you or the world at large. Look for studies with at least 100 participants.
Quick Summary:
In-vitro?
Extract?
Dose?
Toxicity?
Randomized Controlled Trial?
Additional references:
Good info for natural products via subscription (I subscribe, but am not associated with them otherwise): consumerlab.com/
An excellent, free course on how to read medical studies:
coursera.org/learn/medical-...
A YouTube promo for the course: youtube.com/watch?v=VnrBeqJ...
It takes about 17 hours to watch all the videos. You can just zip through the quizzes if you don't care about your grade. Overwhelmingly positive reviews from over 1500 students.
If you just want to watch the videos, there's a YouTube playlist:
youtube.com/playlist?list=P...
=seymour=
Thanks for this very useful post and for illuminating me about my long-believed red herring!
Sloan has neem/Bcl-2 and prostate, nothing on CLL, so I wonder if neem as a potential for CLL fell by the wayside.
Neem induces cell death in prostate cancer cells by decreasing the levels of Bcl-2, an anti-apoptotic protein. Neem-treated monocytes induce apoptosis in cervical cancer cells by increasing levels of caspases 3, 8 and 9, interferon (IFN-gamma), and by decreasing tumor necrosis factor (TNF-alpha) (10). Neem also acts as an antiretroviral agent via inhibition of viral invasion of host cells (5).
mskcc.org/cancer-care/integ...
Lavinia-Blue -
Thanks for that excellent reference!
Note that MSK web site you linked references Neem Oil, not Neem Leaf Powder. I wish there was a similar article for the leaf powder.
It said:
"Cancer
In vitro studies suggest that neem can inhibit cancer cell growth. It has not been studied as a treatment for cancer."
Patient Warnings
Swallowing neem oil has caused severe poisoning in both children and adults.
Side Effects
Oral (Rare case reports): Vomiting, drowsiness, diarrhea, vision loss, toxicity to the nervous system, poisoning, seizures, and brain damage from swallowing neem oil."
Clinical Summary
...
An ethanolic extract of neem leaves reduced the incidence of chemical-induced gastric tumors in mice (9), and neem-treated monocytes induced apoptosis in cervical (10) and prostate cancer cells (11). "
The above studies did not use Neem Oil, or Neem Leaf Powder.
Two of the studies cited were not oral, and not used in-vivo - they used a chemically prepared extract in a test tube or petri dish.
The third was a study in mice that did not assess safety or side effects - hard to tell from the abstract, but if safety was something they looked at, they surely would have mentioned it.
Many, many things can kill cancer cells in a test tube (in-vitro), such as hydrochloric acid, or high heat. The problem is when trying to achieve the same result in the body - serious side effects can result, as they noted earlier regarding poisonous effect of oral Neem Oil earlier in the article. Preliminary mouse studies often sacrifice the mice at the end before side effect or death from the test substance.
As much as I would like to have a low cost, effective cancer treatment, Neem Oil is not it. At some point, a chemical extract from Neem Leaves will probably be developed into a treatment for some kind of cancer (if it hasn't already), but neither the leaves nor the oil have been proven safe for oral ingestion or effectiveness against any kind of cancer.
The only oral use that I can see reported on is dental. Chewing neem leaves has been used in ayurvedic medicine for a long time. Extracts have also been tested successfully in small amounts:
ncbi.nlm.nih.gov/pmc/articl...
The Effectiveness of Herbal Versus Non-Herbal Mouthwash for Periodontal Health: A Literature Review
The review cited a small study from India. There's no indication that safety was assessed:
thejcdp.com/doi/pdf/10.5005...
"A total of 20 participants, each randomly allocated into groups I and II, wherein in the first phase, group I was provided with 0.2% chlorhexidine gluconate and group II with 2% neem mouthwash.
...
A composition of 100 gm of neem sticks were chopped into tiny pieces and ground into coarse powder in a blender for 2% of neem extracts and stored in containers at room temperature. Nearly 60% of the distillate was collected after heating a mixture of 10 parts of water and neem powder continuously that was soaked in water for 2 to 4 hours. Filtration of the collected distillate was done after cooling and then it was dissolved in 1000 mL distilled water to obtain 2% neem solution.(9)
...
participants in group II were asked to rinse using 10 mL of neem mouthwash for 15 days.
...
When compared with 0.2% chlorhexidine gluconate mouthwash, neem mouthwash is considered to be costeffective. Hence, the neem extract can be used as a better alternative mouthwash to 0.2% chlorhexidine gluconate mouthwash in low socioeconomic status population.
Chlorhexidine mouthwash showed a higher impact on the reformation of plaque and inflammation of gingiva when compared with that by neem mouthwash."
Compare this method of extraction with the one from the Nature nimbolide paper. Extracts can differ dramatically in potency. Always ask, "How did they do the extraction?" I think that 10mL of this crude extract is much less potent than the 100-200mg of nimbolide from the Nature paper. I think we can also assume that this 10mL rinse was not all swallowed, and they only tested 15 days of use. Some effects may occur only after long use.
=seymour=
My takeaway from the articles, is that none of this research has yet been done in humans, so none of us here would likely have yet tried it.
The most recent research I could find, from 2019, in squamous cell carcinoma, was done in cell lines in a lab, not in humans.
ncbi.nlm.nih.gov/pmc/articl...
There's some recent work (I think it's behind a paywall so IDK how valid it may be, and whether this was in cell cultures or animals) of a Neem glycoprotein seeming to help cancer as a modulator of the supportive microenvironment that many cancers surround themselves with, not as a specific ani-cancer agent directly.
sciencedirect.com/science/a...
SofiaDeo -
I notice that the first paper you cite on squamous cell tumors uses Highly Pure Neem Leaf Extract, SCNE. I tried to follow some of the references, but could only find that that extract is unusual in the apparatus needed for preparation. They did both in-vitro and in-vivo tests, but safety was not assessed in that study.
The second paper, a review or summary, references a substance that I found in 75 other papers, Neem glycoprotein (NLGP). So it seems to be a hot topic. That paper makes no reference to dosage or safety.
I found a paper that shows how NLGP was prepared:
ncbi.nlm.nih.gov/pmc/articl...
"Mature leaves of the same size and color (indicative of same age), taken from a standard source, were shed-dried and pulverized. Leaf powder was soaked overnight in phosphate-buffered saline (PBS), pH 7.4. Supernatant was collected by centrifugation at 1500 rpm, extensively dialyzed against PBS, pH 7.4, and concentrated by Centricon membrane filter (Millipore Corporation, MA, USA) with 10 kDa molecular weight cut-off. Purified NLGP was checked for its quality by electrophoresis and HPLC using routine laboratory methods."
I point this out because NLGP may not be the same thing as consumer Neem Leaf or Neem Leaf Extracts.
=seymour=
Thank you for all comments here. I'm reading the articles.
I use Neem oil to spray my plants, trees, fruit and vegetables.
I spray tree trunks with it to eradicate certain fungus.
If I was nearing treatment and had nothing to lose so to speak I would try this. What if it helped? During earlier stages of the disease I would better not try it because what if it made things worse? Are you nearing treatment?
I read a lot of medical articles, but this discussion is sufficiently over my head that I wouldn't be trying it. If it is effective, I will expect more ncbi articles soon, including one or more specifically discussing CLL. I'm with you, Pvasile, in that I'm always looking at natural stuff, and earlier on, anything that said "leukemia" had me excited. I have learned that might not in fact have anything to offer because of so many kinds of leukemia.
Regarding your question if anybody has tried it, I have been taking Neem for about 4 month now. It was originally recommended by my acupuncturist as an anti inflammatory herb similar to turmeric. My doctor had told me about the anti inflammatory properties of turmeric about 8-9 years ago. But I use turmeric with caution because it thins the blood too much. I had no idea that Nimbolide could have an impact on CLL cells. I will definitely look for additional research in the use of neem and Nimbolide. Let me add that I am in W&W so I feel comfortable trying new herbal supplements. But, I would be more cautious if I was already taking medication to treat my CLL. Thanks for your posting… 🙏
pubmed.ncbi.nlm.nih.gov/337...
Has the Neem helped with inflammation? Does it seem to work as well as Turmeric?
It doesn’t work as well for inflammation as turmeric, but I have to be very careful with turmeric because I have a tendency to have nose bleed. But what I noticed with neem is that it helps with to move the bowels. Another reason to be careful and not to over do it… 😆
Could you please tell me how you assess inflammation?
Pvasile -
This is interesting, even if it's not specifically for CLL cells.
The Nature paper says:
"Through a systematic approach combining in silico computational techniques and experimental methods, we investigated nimbolide to ascertain its exact protein targets and decipher its mechanism of anti-tumor activity in B-cancer cells. As such, this is the first mechanistic analysis of nimbolide demonstrating 1) its activity in WM cancer cells in vitro, 2) the use of virtual screening methods to classify its molecular targets and 3) its ability to be safely administered and produce anti-tumor effects in an in vivo model of hematologic malignancy."
...
"We hypothesized that systemically delivered nimbolide would engage its target(s) in vivo to induce WM cell death at pharmacologically achievable doses. Using our murine xenograft model of WM,26 we administered nimbolide via intraperitoneal injection in two separate cohorts of mice, testing two doses, 100 and 200 mg kg."
That's a pretty huge dose of anythingit's not the dose of Neam Leaf Powder, but of the nimbolide extract. Assuming a 200lb/91kg person, the dose would be 9.1 to 18.2 grams, injected, not swallowed. But it was done over several days at 50mL/day (see below) No toxicity tests were done on normal mice. Given the notable off-target effects of many drugs, there are likely similar off-target effects for nimbolide.
In the Supplementary Methods section, it said:
"NLE [Neam Leaf Extract] was prepared using the dried leaf powder from the capsules (Nature’s Way, Springville, UT) and was made to a final concentration of 12.5% (w/v) in absolute alcohol by incubating the leaf powder in ethanol overnight and collecting the supernatant after centrifugation at 14,000 x g for 10 minutes, followed by filtration. Nimbolide, Bortezomib and Ibrutinib (PCI-32765) were purchased from Biovision (Mountain View, CA, USA).
...
Twenty female SCID mice (10 weeks of age) were subcutaneously implanted with 1x106 RPCI-WM1 cells, which formed localized tumors that secreted detectable human IgM in the serum by Day 14. On Day 10 post-implantation, the mice were randomized into 3 groups and received either DMSO (n=6) or nimbolide formulated in DMSO (100mg/kg, n=7; or 200mg/kg, n=7) at a final volume of 50ml every alternate day for 26 days via intraperitoneal injection. ""
So, they looked at Neem Leaf Extract for one aspect of the experiment, but they bought already extracted nimbolide for use in the mouse study.
---
The supplemental info on the second paper:
ncbi.nlm.nih.gov/pmc/articl...
A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL
"the extreme cost of nimbolide (2020 Sigma price = $77,000 USD/gram) making small-scale, multi-step synthetic manipulations of this acid-sensitive scaffold highly challenging. Commercial neem leaf powder (Azadirachta Indica extract), however, remains a popular and inexpensive health supplement containing varying amounts of nimbolide. Using a newly devised extraction protocol (see Supporting Information), we were able to obtain gram quantities of analytically pure nimbolide from a single 1 lb. can of Organic Veda™ neem leaf extract (2020 price ~ $30 USD) without the need for HPLC purification (Figure 1)"
They showed the following info if you want to try to reproduce the results - I relate all this to show the complex chemistry of extraction, and how little extracted chemical results:
"General Procedures
Unless otherwise noted, all reactions were performed in flame-dried glassware under positive pressure of nitrogen or argon. Air- and moisture-sensitive liquids were transferred via syringe .Dry dichloromethane, N,NDimethylformamide and tetrahydrofuran were obtained by passing these previously degassed solvents through activated alumina columns. Organic Neem leaf powder from Organic VedaTM (16 Oz. can, organicveda.com/neem-leaf-p... was purchased through Amazon.com. N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide was purchased from Combi-Blocks Inc."
...
Supplementary Procedure 1. Isolation of nimbolide from commercial neem leaf powder
Initial Extraction. To a 3 L round bottom flask containing 1 lb. (~450 g) of Organic VedaTM neem leaf powder and a large stir bar was added 1.5 L of anhydrous methanol [purified wood alcohol] and the resulting suspension was stirred for 12 hours at room temperature in a fumehood with the lights off. The mixture was then filtered through a short pad of CeliteÒ (typically in 5 portions for faster filtering, filtration takes >1 hour) and the solid was washed with additional methanol until the CeliteÒ layer was white colored (see SI-figure 1B). The filtrate was concentrated in vacuo at 30 °C to provide a dark green oil which was partitioned between EtOAc [Ethyl Acetate - nail polish remover] (500 mL) and water (300 mL). The phases were separated, and the aqueous layer was extracted with additional EtOAc (250 mL). The combined organic layers were washed with a mixture of saturated aqueous NaHCO3 [sodium bicarbonate] and Na2S2O3 [sodium thiosulphate] (9:1 v/v, 250 mL), dried over Na2SO4 [sodium sulphate] and concentrated in vacuo to afford a dark green oil. Thin layer chromatographic (TLC) analysis of this mixture is shown in SI-Figure 1D.
...
Trituration to obtain analytically pure nimbolide. The dark brown solid obtained after the 2nd column was diluted with 3 mL of CH2Cl2 [dichloromethane - methylene chloride], followed by the addition of 20 mL of pentane. A brown solid precipitated out of solution and the liquid phase was removed by pipette. The solid was triturated 2 additional times in the same way (3 mL of CH2Cl2 [dichloromethane ] then 20 mL of pentane) to furnish nimbolide as a white solid. A range of 1.1 g – 1.3 g of pure nimbolide was isolated using this procedure. No attempts were made to further purify the mother liquor which still contains significant quantities of nimbolide."
Sounds like serious Breaking Bad level chemistry!
So from a pound of Neem Tree Leaf powder, they purified 1.1-1.3g of pure nimbolide, and left some nimbolide behind. They used this nimbolide in-vitro. The Nature paper used the equivalent of several pounds of powder.
---
In conclusion, I think it's a huge stretch to go from raw neem leaf powder to an oral treatment for cancer. The papers were not testing neem leaf powder, they extracted a Nimbolide from the powder using a bunch of additional chemicals and apparatus.
I checked ConsumerLab.com, and found very little info on Neem so far. I'll request that the review it.
HealthLine had a few warnings for oral usage, but powders and oils may have different action:
healthline.com/nutrition/ne...
Other warnings from a non-vetted web site:
stylecraze.com/articles/sid...
Note that raw neem leaf is mostly used topically in small amounts, and can be used as a pesticide.
=seymour=
Based on clinical research of efficacy for both of my cancers (CLL + PCa), I have been taking Neem Leaf Extract (NLE) for at least three years. I use the same dosage and supplement supplier (~1000 mg Nature's Way Neem Leaf twice a day) as the patient profiled in a Mayo Clinic paper linked below. (Abstract only.) The research paper is now behind a paywall, but I have the full article in PDF format in pre-publication form and will be happy to provide it via PM to anyone who wants it. The following excerpt explains why Mayo decided to undertake their small trial and includes the conclusion from that pre-pub paper:
* * *
Oral intake of NLE induces remission in a patient with CLL
Our pre-clinical evaluation demonstrates for the first time the pro-apoptotic effect of NLE in primary leukemic cells from patients with CLL and confirms prior pre-clinical observations of its antineoplastic potential in solid tumor models [17,19,21,23,24]. Interestingly, our investigation was initiated by the observation of remission induction in a patient who self-administered NLE. This patient had previously untreated, symptomatic Rai stage II CLL with rapid doubling time and chose NLE treatment over recommended standard chemotherapy. Treatment with NLE (1000 mg twice daily) resulted in unconfirmed complete remission (CR) that lasted for 44 months (Figure 6E).
And from the DISCUSSION section:
In conclusion, the data presented in this report demonstrate that NLE induces apoptosis in CLL cells by simultaneously invoking autophagy and apoptosis. The cross talk between these mutually exclusive yet complementary cell death pathways is complex and several molecular regulators including Bcl-2 and p53 play a critical role in the process [47]. By inhibiting these proteins, NLE may initiate the apoptotic process. As progression of asymptomatic CLL to its aggressive disease form involves the accumulation of the Bcl-2 family of proteins (25, 42) as well as loss of p53, treatment with NLE could be a potential therapy. The observed remission in a CLL patient (Rai stage II) further emphasizes the potential benefits of NLE therapy for the treatment of CLL.
* * *
Here is the link to the published Abstract:
Neem leaf extract induces cell death by apoptosis and autophagy in B-chronic lymphocytic leukemia cells - doi: 10.3109/10428194.2013.807927. Epub 2013 Jul 1.
tandfonline.com/doi/abs/10....
There are also quite a number of papers profiling the possible benefits of NLE in protection from COVID. Here is a link to one of those:
Neem (Azadirachta Indica A. Juss) Capsules for Prophylaxis of COVID-19 Infection: A Pilot, Double-Blind, Randomized Controlled Trial
pubmed.ncbi.nlm.nih.gov/338...
Please do your own research and discuss the use of any and all supplements with your medical professionals. Good Luck and Good Health to All.
Ciao – Captain cujoe
Do you feel any improvements after taking it ?
Good question with no good answer. I am an “outlier” for both cancers and the addition of NLE two+ years back is mixed in with any number of other diet, lifestyle, supplement, and treatment (Pca only) changes, so that the influence of any one is impossible to determine. As an outlier, I have “beaten the odds” (so far!) for both cancers and, barring something like Richter’s, am further away from treatment for CLL than ever.
My CLL was diagnosed via biopsy of a lymph node removed from my neck in 2006. I am fortunate to be in the indolent 1/3 of CLL patients, with a 13q14.3 double-deletion and mutated IgVH status. After having my white counts reach a peak at 3 x normal range about three years after diagnosis, it plateaued and then gradually declined to remain in the normal range over the last 2+ years. In fact, other than platelets, all CBC/CMP results have been within or right at normal ranges for those same 2+ years. Absent the single remaining tiny palpable clavical node, the low platelets, and low IgG/IgM immunoglobulins, I might well be considered to be in remission. Having never had any classic CLL symptoms or any other issues that might be related to a deficient immune function, I consider myself to be a very lucky person – and try daily to act accordingly.
Thank you for sharing your experience and congratulations on your success in controlling your disease with your very thoughtful and rational approach. I have used neem from the same supplier with great benefits prior to developing CLL. It’s a fascinating plant with such a long history of use. I will have to consider adding it at some point in the future. Currently I’ve got way too many things going on to comfortably add in another variable to my regimen.
flipper,
You are correct about the very diverse uses and interesting history of the Neem plant. I currently take 2 caps first thing in the morning and at night before bed. The correlation of my improved blood labs with the addition of NLE to my other supplements/diet/lifestyle mods is just that, a correlation - as my blood work was trending towards the near normal ranges (sans platelets) before I added the NLE. I can, however, report that, in my case, liver and kidney functions have not been affected in the least by 2+ years of NLE.
I see in some of your previous responses that you have experience in pharma development, so I'm pretty sure you do your homework and tread lightly where supplements and SOC are involved. Also, as a result of that experience, I would expect that you have insights most CLL patients lack . . . So, Thanks for your input and Very Good Luck to you and your treatment strategy.
Ciao - cujoe
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