Neanderthal DNA on Chromosome 12 Protective a... - CLL Support

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Neanderthal DNA on Chromosome 12 Protective against Covid 19

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COVID-19 Protection and Geographic Distribution.We find that the index variant of the protective haplotype in the GenOMICC study (rs10735079, P = 1.7e-8) matches all three Neandertal genomes available. The relative risk of needing intensive care is reduced by ∼22% per copy of the Neandertal haplotype (under the rare disease assumption, odds ratio [OR] = 0.78, 95% CI 0.71 to 0.85). As expected given the phylogeny (Fig. 2), almost all of the alleles cosegregating with the protective allele of the index SNP are found in the Neandertal genomes (34 of 35 called SNPs; see SI Appendix, Table S2, which, in contrast to Fig. 1, includes data contributed by 23andMe to HGI).Today, the haplotype is almost completely absent in African populations south of the Sahara but exists at frequencies of ∼25 to 30% in most populations in Eurasia (Fig. 3). In the Americas, it occurs in lower frequencies in some populations of African ancestry, presumably due to gene flow from populations of European or Native American ancestry (33).

I am fortunate to have this luckily I had DNA mapping due to being adopted and searching my heritage. Hope this is true,

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