Atypical cll

[tms99532]

Hi I was diagnosed with Atypical cll in 2014,currently W/W

I' m 13q delected and IGHV mutated

FISH as below

CD3+ T CELL

CD3- NK CELL

CD5 weak B CELL

CD10- B CELL

CD19+ B CELL

CD20+ B CELL

CD23- B CELL

CD56+ NK CELL

CD79b weak B CELL

CD200 weak B CELL

FMC7- B CELL

CBC today as below

HGB 13.5

Platelet 232

Neutrophil 3.55

Lymphocyte 14.4

What's mean ATYPICAL CLL

[cajunjeff]

I’ll give you a laypersons shot of an answer, most of it’s over my head.

Cll is a bcell cancer. Bcells are a type of lymphocyte, lymphocytes are a type of white blood cell.

To determine if we have Cll, doctors look at a test called flow cytometry that looks at molecules on our cell surfaces. Our bcells have certain proteins on their surface. These proteins are identified by a numbering system for clusters of differentiation (CD).

Typical Cll cases show expressions of CD 5, CD 19 and CD 23, along with other markers. Other bcell cancers are identified by CD groups as well. When a pattern of CD expression is close to Cll, but doesn’t fit it exactly, it can be called atypical Cll. Atypical Cll often involves expression of CD 200, which is notable in your labs.

Sometimes atypical Cll can be more aggressive than typical Cll. Your atypical Cll is accompanied by mutated IGHV and 13q deleted, both very favorable markers. I would think your version of atypical Cll might not be as aggressive as other versions thanks to your favorable FISH and IGHV findings.

Of course your doctor would be the best person to ask what prognostic implications, if any, there are for you having atypical Cll. I would think the treatment for typical and atypical Cll would be the same. I would think being 13q and having mutated IGHV are favorable markers, both for typical and atypical Cll.

[tms99532 in reply to cajunjeff]

CD23- is this marker of MCL ?

CD200 weak that means positive or negative ?

Expression that means positive or negative ?

[AussieNeil Administrator in reply to tms99532]

Expression means the marker was detected. Whether a marker is noted as being positive or negative depends on whether the marker is above or below a threshold. Above or 'bright', is positive, below, or 'dim', is negative. The threshold varies by marker. Sometimes there isn't an agreed threshold, there could be more than one.

Patterns from all the markers are used to identify different blood cancers.

Added: CD23 is found in both B and T lymphocytes.

en.m.wikipedia.org/wiki/CD23

Neil

[AussieNeil Administrator]

That would be asymptomatic CLL.

[cllady01 Former Volunteer]

"Other cases may co-express CD19, CD5, bright CD20, and lack CD23 ("atypical CLL")" --

this was a statement I copied from a description of MBL---and is an example of an atypical CLL description. It has to do with the profile findings of Flow Cytometry Testing.