COVID antibodys

[studi]

I am sure that I did not make it clear the last time I posted a few days ago.

There were 2 people on the site where I did not get there names,but after 2 vaccinations they still had no antibodies.They both said on there 3rd booster jab that they did have antibodies.Could they please say is both were on W W or were they on treatment.I thought that treatment ie ibrutinib destroyed the antibodies.

I am on treatment and thought it would give me hope to get some antibodies if they have been tested and are on treatment.

Thanks to you all for great support

Trafford Reeder

[AussieNeil Partner Administrator]

No CLL treatments destroy antibodies, they just reduce the available number of new B cells which are required to respond to vaccinations.

[Youngen]

I am one of the people who posted previously. Had no response after the first two and developed antibodies after the third. I am currently in treatment (Ibrutinib). Have heard of many others (Israel) that only developed antibodies after the third and expect them to publish the results shortly.

[lankisterguy Volunteer]

Hi studi,-

I am one of the members that reported having measureable antibodies (101) after my 2nd COVID-19 vaccination, despite being 73 years old and on daily Venetoclax (but no Obin/Gazyva or Rituxan in the last 5 years).

I got a 3rd shot and will have my blood tested tomorrow.

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As AussieNeil said, there are no absolutes in the results from CLL patients on active treatment getting the COVID-19 vaccines.

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The clearest explanations I have seen are by Dr. Brian Koffman summarizing a paper presented by Dr. Lindsey Roeker here:

cllsociety.org/2021/07/ash-...

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SNIP

A previous study from Israel had disappointing results with only 40% of 167 CLL patients producing antibodies in response to the COVID-19 vaccine. This showed that vaccine response is impaired in patients with CLL.

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This new data from Dr. Roeker and colleagues provide additional information from a group of 44 patients with CLL who received two doses for either the Pfizer or Moderna COVID-19 vaccines.

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Antibodies were checked at least 2 weeks after receiving the second dose of the vaccine.

17 out of 18 patients (94%) who had never been treated for CLL formed antibodies.

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Only 6 out of 26 patients (23%) who had previously received treatment for CLL formed antibodies.

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Patients who were currently on a BTK inhibitor were much less likely to produce antibodies.

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Patients who had been treated with an anti-CD20 monoclonal antibody within the past year were much less likely to produce antibodies.

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None of the patients treated with venetoclax + an anti-CD20 monoclonal antibody within the past year formed antibodies.

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Patients who were less than 70 years of age were more likely to form antibodies.

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Patients with CLL should still exercise caution including avoiding contact with people that are sick, wearing a mask in crowded situations, and washing hands.

While antibody response is important, it is not the only part of the immune response. T cells also play an important role because they seek out and destroy cells that are already infected with the virus.

In theory, T cells could help provide some protection against COVID-19 by clearing out the infection and reducing the severity of the disease, and scientists are working to figure out whether T cells actually do have protective effects.

As more people are vaccinated, the risk of infection goes down for everyone.

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Len

[LeoPa]

You can't count on having the same result as others. It seems pretty individual.