Anyone have information on Quercetin?

[CBME]

I have been reading about Quercetin - don't know enough to make any determinations good or bad but the information out there relative to CLL is very interesting. Does anyone have any information or have spoken to their doctors about it?

[lankisterguy Volunteer]

Hi CBME, -

Here is a link to a list of 8 past postings where Quercetin was mentioned.

healthunlocked.com/cllsuppo...

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The list referenced above includes this discussion by 70s-80s-overlander

healthunlocked.com/cllsuppo...

about using Quercetin along with EGCG and Curcumin, his post includes links to other past postings on those combinations, and the challenges and side effects of that regimen.

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Here is what WebMD says:

webmd.com/vitamins-and-supp...

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And a NCBI - NIH paper from China that explores many different varied results,

ncbi.nlm.nih.gov/pmc/articl...

but mentions a possible immune booster effect, which should be carefully reviewed since boosting B-cells could also encourage CLL cell growth, which we do not want.

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In the WebMD article you will find this comment:

Can you get quercetin naturally from foods?

Quercetin is abundant in nature and foods. People typically get between 5 and 40 milligrams a day from food. But if you eat lots of fruits and vegetables, you can get as much as 500 milligrams daily.

For example, think "quercetin" the next time you pour a glass of red wine, bite into a crunchy apple, treat yourself to some berries, flip a buckwheat pancake, slice an onion, or sip a cup of green tea. Other vegetables that have high amounts of quercetin include:

Kale

Tomatoes

Broccoli

Raw Asparagus

Capers

Raw red onion

Nuts and seeds

Olive oil

Red grapes

Cherries

Quercetin is also in herbs such as:

American elder

St. John's wort

Ginkgo biloba

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Len

[CBME in reply to lankisterguy]

Thanks. It is so hard to know what is good for you and what is not. I read that in low doses Quercetin can actually be bad for CLL. But that is not repeated in all articles. Hard to know. . .

[Vlaminck in reply to CBME]

If you don't mind, may I ask where you have read that low dose could be bad? I mean, we all get low doses from our food every day, although I'm taking 500 mg a day. Thanks

[CBME in reply to Vlaminck]

I will try to go back and find that. It was one sentence in a whole lot of good stuff. Will look back tomorrow and let you know.

[Vlaminck in reply to CBME]

Thanks!

[CBME in reply to Vlaminck]

Here is the article. Read the section on Leukemia growth - it is stated in the last sentence of that section.

plantmedicines.org/querceti...

I thought it was an interesting article on Quercetin. There is much written on the benefits - this was the first mention I read on a drawback to it.

[CBME in reply to lankisterguy]

I am wondering what you think of this article. Read the last sentence in the leukemia section.

plantmedicines.org/querceti...

Thanks for letting me know what you think.

Nina

[Vlaminck in reply to CBME]

Thank you, Nina. That one comment, that low does encourages leukemia, seems almost a throwaway with no explanation or source at all. Scary to see such a comment, and I believe most of us get over 100 um (which I think = 100 mg), but still, how would small dos increase leukemia. For what it's worth, here is a very recent article on quercetin and CLL. pubmed.ncbi.nlm.nih.gov/336...

[Vlaminck in reply to CBME]

Following up on my reply just posted -- maybe low dose helps leukemia the way lose doses of any vital, important nutrient tends to help cancer -- as in too little vitamin C, too little vitamin D, etc. So you could say, I guess, that "low dose" of Vitamin D favors leukemia --? I mean, the fruits and veggies with quercetin, if you didn't eat any of them, would mean you are hurting your health. ????

[CBME in reply to Vlaminck]

Can you resend the link you provided to the recent article. I copies it and it sent me to some invitro anti-allergy page. Oops. Thanks. And yes I thought the statement odd in the article I shared, and as there is no date, I did contact the publisher to get more information. And I don't know enough to translate the low dose amount into mg's or anything else. How low or high is that? I have no clue.

[Vlaminck in reply to CBME]

Oops, sorry if sent wrong one. Here is link (and I see it looks different) ncbi.nlm.nih.gov/pmc/articl...

[AussieNeil Administrator in reply to CBME]

Hi Nina,The research you referenced is about a Chronic Myelogenous Leukaemia, (CML), not a B cell Lymphocytic Leukaemia/Lymphoma

"K562 cells were the first human immortalised myelogenous leukemia cell line to be established. K562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis.[1][2] The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes[3] and erythrocytes.[4]"

en.m.wikipedia.org/wiki/K56...

There is some quercertin CLL related research, but most of it is mouse model research. I did find this human study,

pubmed.ncbi.nlm.nih.gov/294... but you really need a blinded randomised controlled trial to determine whether quercertin has any useful effect on CLL. See

healthunlocked.com/cllsuppo...

Neil

CLL develops in the lymphoid stem cell line (right), not myeloid stem cell line (left)

[CBME in reply to AussieNeil]

That was 3 years ago. I think I am ok with my new levels. Just wanted to know if anyone knew anything different. I love the support here. Thanks so much