Hi , recently I have been informed that my CLL is T cell related . TPLL does anyone have any information on this ?

[333butterfly]

Hi , recently I have been informed that my CLL is T cell related . TPLL does anyone have any information on this ? Having seen 2 consultants one says it’s LGLL and the other TPLL . I’m confused. What markers differentiate the two? Any advice would be helpful, thank you .

[Jm954 Administrator]

There are several types of lymphocytes CLL arises from B cells and TPLL and LGL arise from T cells. They are very different diseases to B-CLL and need different treatment which varies according to the type of T cell Leukaemia. Prognosis varies according to the type and you mention both TPLL and LGLL which are different with TPLL being much more aggressive. LGL, like CLL, can be very slow or more fast growing.Here is the LC information about LGL.

leukaemiacare.org.uk/suppor...

LLS information for LGL:

lls.org/leukemia/large-gran...

and for TPLL:

lls.org/leukemia/t-cell-pro...

LC have a group on HU that you might find helpful:

healthunlocked.com/leukaemi....

I hope this helps

Jackie

[333butterfly in reply to Jm954]

Thanks Jackie , these are really helpful 👍

[Smith123456]

based on my own experience-i have b-pll- sometimes these things are hard to give an exact diagnosis. as one doctor said to me about mine-yours is a mish-mash. Yours could have similiar issues.

[333butterfly in reply to Smith123456]

Yes , the words mish mash sound familiar !!

[lankisterguy Volunteer]

Here is a link to the 49 previous posts that mention b-pll healthunlocked.com/cllsuppo...

Many of them are from members that say they have b-pll

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And 6 postings for LGL: healthunlocked.com/cllsuppo...

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It is frustrating that the T-cell lymphomas seem to lack distinct markers and take a long time for diagnoses to be pinned down. You may need to get referred to a Leukaemia expert at one of the major hospitals in the UK, and then it may still a blurry differential diagnosis.

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If you can read dense med-speak here are some papers that talk about the complexity of distinguishing the two lymphomas:

pubmed.ncbi.nlm.nih.gov/159...

onlinelibrary.wiley.com/doi...

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Len

[333butterfly in reply to lankisterguy]

Thank you Len , really appreciate your response 👍

[DriedSeaweed]

It seems to me it would be rather important to pin down what it is before treatment. Can you find specialists in those areas to help you rule out one?

[bkoffman CLL CURE Hero]

Rarer cancer that at one time was classified as a type of CLL, but they now have known for a long time it is a different leukemia. Try to find an expert.