CLL and Mayo Clinic EGCG Phase I and 2 trials (Pharmaceutical grade Polyphenon-E derived from Green Tea)

[Alpha66]

I believe some research is in progress at the Mayo Clinic evaluating the effect of EGCG from green tea on CLL progression as it appears to slow down the disease development.

[AussieNeil Administrator]

You must be accessing the Way Back Internet archive, because that research is from around 10 years ago. It was funded by CLL Topics/Updates members and initiated by Chaya Venkat, who went out to tender for an experienced research group to manage the study. A Japanese company Mitsui provided their Polyphenon-E product, only to later swith to using it in genital wart preparations, so it was no longer available to those with CLL. I'd say that EGCG is the best studied natural remedy for CLL, yet it doesn't work for everyone and there's been no follow-up. 31% of those in the trial didn't see a biologic response (i.e. they had no statistically significant reduction in lymphocyte count or node size). Mayo Clinic did patent EGCG in combination in conjunction with chemo drugs from that era. See:

- healthunlocked.com/cllsuppo...

- healthunlocked.com/cllsuppo...

- healthunlocked.com/cllsuppo...

Back then there was no understanding of clonal evolution in CLL, so we don't know how green tea influences that, plus one of the Mayo Clinic researchers involved in both studies, Dr Neil Kay, specifically warned those with CLL not to take over the counter EGCG preparations, because due to the unregulated herbal supplements industry in the USA and pretty well every other country, we don't know what's in what's actually sold. With the efficacy of modern treatments, particularly if you have access to non-chemo treatments, it's arguable that its time has passed.

Neil

PS I've taken the liberty of correcting your spelling of EGCG in your title and expanding the title, so that you should get more references in the Related Posts section below or to the right of your post.

[Hoffy]

See my past posts. It did not work for me because my CLL is too far along. If you do it work with a doctor to monitor your liver enzymes.

Be well,

Hoffy