What's the deal with CRP

[djgolding]

for my next set of bloods, the haematologist has asked for CRP, which I am assuming is C-Reactive Protein as a tumour marker. Has anyone any info on this? I'm kind of looking at a low value as positive news, what do ppl reckon?

[djgolding]

found this idosi.org/aejsr/5(1)10/6.pdf

[Mijoed]

If you have an infection, protein is released and this can be detected in CRP. Not sure about being a tumour marker but certainly in the case of checking for infection, low is good.

[djgolding in reply to Mijoed]

I like "low is good"

[Cllcanada Top Poster CURE Hero]

There is CRP and hs-CRP... it isn't a standard CLL marker test as such... that I'm aware of...

other than perhaps an indication of disease load, inflammation and perhaps autoimmune problems...

Hs-CRP

'C-reactive protein (CRP) is a protein produced by the liver and released into the bloodstream. The level of CRP in the blood increases with inflammation and infection as well as following a myocardial infarction (MI, heart attack), surgery, and trauma. Thus, it is one of several proteins that are often referred to as acute phase reactants. The high-sensitivity test measures small amounts of CRP in the blood in order to help evaluate a person's risk of developing cardiovascular disease (CVD).

There are two different tests that measure CRP: the standard CRP test and the high-sensitivity CRP (hs-CRP) test. Each measures different ranges of CRP levels in the blood for different purposes. The standard test measures markedly high levels of the protein to detect diseases causing significant inflammation. The hs-CRP test can more accurately detect lower concentrations of the protein than the standard CRP test and is used to evaluate individuals for risk of CVD.'

labtestsonline.org/understa...

CRP

'C-reactive protein (CRP) is an acute phase reactant, a protein made by the liver and released into the bloodstream within a few hours after tissue injury, the start of an infection, or other cause of inflammation. Markedly increased levels are observed, for example, after trauma, heart attack, with autoimmune disorders, and with serious bacterial infections like sepsis. The level of CRP can jump a thousand-fold in response to an inflammatory condition, and its rise in the blood can precede pain, fever, or other clinical indicators. The test measures the amount of CRP in the blood and can be valuable in detecting inflammation due to acute conditions or in monitoring disease activity in chronic conditions.'

labtestsonline.org/understa...

~chris

[Cllcanada Top Poster CURE Hero in reply to Cllcanada]

I did more digging CRP is related to Interleukin IL6 levels... and these HAVE been looked at in CLL ... however most of the research is over 10 years old...

clincancerres.aacrjournals....

[djgolding in reply to Cllcanada]

Thank you Chris - felt the need to know more. I'll ask why when I do my next set of chemo.