Does anyone think/know that certain medications eg Omoparazole contribute to a fatty liver

[togothewonderdog]

I'm new here, I got diagnosed with fatty liver around 6 years ago but was told it was mild (but not what grade?) I work in the music industry particularly DJing so its hard to not drink being around it so often (and its free!) I have cut down since then though even more so the past year since the pandemic, and have only had 4 drinks in 10 weeks now but have been quite ill past 3/4 weeks

I've had stomach pains, been feeling wiped out, occasional jaundice (that can last between 10 mins and few hours and not in the eyes) and off/on itching, i've had various tests and my bloods seem fine part from bilirubin was ok 2 weeks ago then slightly raised at 1.9 this week

I'm having endoscopy next week and MRI week after, from the ultrasound they said the liver still looks "a little fatty' and there is a mircocyst but they are not to worried but want to look more with the MRI, they have ruled out parasites

I have taken Omoparazole off and on for a long time (approx 20 years ) I suffer badly from acid reflux even when I don't drink and change foods, I have read that in can contribute towards a fatty liver which makes sense as its a toxin with prolonged use, just wondered if anyone had any thoughts

glad to find this forum

thanks

[gnillo]

Hello and welcome, I have been prescribed omeprazole for the last 30 days or so for an h-pylori infection and docs weren’t concerned with the length of time but did mention how proton pump inhibitors (PPI) can cause gut issues if taken for long periods of time. In regards to ur bilirubin and being jaundice have they looked at Gilbert’s Syndrome? I don’t know anything aside from what ur post says but if all of ur other blood work is normal and scans don’t reveal anything it might be worth a shot. I was diagnosed with Gilbert’s a few months ago and all of my numbers have returned to normal range aside from indirect bilirubin and my total bilirubin is usually raised but not my much outside the normal range. When my numbers were elevated I had RUQ pain, sensitivity to foods, itchiness... Check out the NHS link on Gilbert’s Syndrome. Good luck and hopefully u get some clarification soon. nhs.uk/conditions/gilberts-...

[togothewonderdog in reply to gnillo]

Thanks for your reply I’m having an endoscopy next week so they will be able to check if it’s Gilbert’s syndrome then I was thinking it might be that

I’ve had 2 endoscopies before but last one was around 8 years ago that was fine but the first one 15 years ago revealed slight oesophagitis and they told me to keep on the omoporazole but I’ve not wanted to take them the rest of my life but do seem to struggle without them even when I cut out alcohol for weeks and acidic foods

Let’s see !

[gnillo in reply to togothewonderdog]

I have my first endo/colonoscopy scheduled for next week so hopefully everything is clear. Wishing u well on urs as well and hopefully u don’t have to keep taking the PPI. Keep me updated on ur possible Gilbert’s too. I’m sure ur like me and hate waiting for answers. Lol. Cheers!

[togothewonderdog in reply to gnillo]

Hey How was your endoscopy/colonoscopy?

My showed a small hiatel hernia and gastritis

I had biopsies taken but they came back negative for h pylori (which I’ve had twice before )

The doctor diagnosed IBS which I’ve been diagnosed with before years ago but I feel it’s a term doctors use when they don’t really know what’s causing the problems ..!?

I was prescribed antispasm medications and told to only take the Omoparazole if the acid reflux was bad

I’m currently trying to reduce the frequency (again something I’ve done before) watching my diet / laying of the alcohol

I have been having other health issues, eye infection, skin rash, headaches all since I had covid last October and I can’t help but think that has something to do with everything going on now, as if the covid has really effected the whole immune system ?

[gnillo in reply to togothewonderdog]

Hi, I’m sorta in the same boat as u. It seems like my health has taken a down turn in the past 8 months. I found a new Hep and met with her last week and I am absolutely pleased with her thus far. Colonoscopy went well, removed 2 benign polyps but my endoscopy shows significant villus blunting so it’s suspicious of celiac disease. However, I’m seronegative on the blood testing (tTg, Gliadin) but my IgA is over 1000 mg/dL (range is 0-400), there’s genetic pairing but my GI doesn’t seem to want to sort this out. He wants to refer me to an allergist/immunologist so I think it’s time to call their higher in command and explain celiac is not a simple peanut allergy so to speak. Lol. I also have to get an MRI after there were some issues with my spine so that’s also needing some sorting out. I read on IBS before and ur right about docs diagnosing that often when they can’t really find a source for issues. Sucks for sure.

On a side note, I’m still sober and love it. Just want to get this health stuff sorted out. Definitely wonder how COVID has played out in this as my new hep believes it has something to do with my ongoing issues. How u holding up with everything?

[Chris-harris]

At my last endoscopy and due to acid / stomach issues i was prescribed omoporazole, this was over 12 months ago and my liver does not seem to have been impacted, in fact it was my liver consultant that prescribed them

[togothewonderdog in reply to Chris-harris]

Thanks for your reply Buy I’m talking about 15 years plus of taking them !