It’s all foreign to me but someone here might translate it into human words?
New cirrhosis research.: It’s all... - British Liver Trust
New cirrhosis research.
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Brett11
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Well now that's promising. Even if only tested on rats! .Will be too late for me anyway if it is ever used on humans and passed by the GMC lol
😂😂😂😂 nope I can't translate it !
Hi Brett, I have for some time now become quite regimental in what sites Dr Google throws up. I tend to steer away from American sites as they can be scary and a bit alarmist. I stick to English sites as they do seem to be more pragmatic and logical.
That's not to say I don't read articles from other countries, as I do. There's some really exciting work being carried out in Adelaide, Australia between the bodies immune system, alcohol and the liver. A lot of this research and it's findings are/is shared with other institutions like the University Hospital in Birmingham.
Sadly I know that it won't happen in my lifetime, but I believe that one day, liver transplants will become a thing of the past. I can just see kids of the future walking round museums and asking Dad or Mum, "Did they really take livers from dead people and swap them with other ones?".
Just a thought (and allowing my vivid imagination to run away from me).
Good luck Brett.
That’s true. We will all be pushing up daisies before then.
Here's the secret: milesofchocolate.com/?page_... Wish I had the recipe. I would share it with all of you. We could eat chocolate every single day, and talk about that instead of advanced liver disease. It is puzzling that I have never had a serious sweet tooth before now, but I'm indulging it. I will be 72 next month and am not convinced that I actually want to be around for more than, say, another 10 years, even in the best of circumstances. I've had a very interesting life, sooooo...
A lady after my own heart lol. I used chocolate for instant energy when I was at my lowest. It worked!! I still eat chocolate every day but no where near a full block like before. Just 4 pieces a day now! Talk about going cold turkey on it haha
Back to Brett's original post. When reading such reports, I no longer try to look up every single strange word; I simply scan for what I sorta understand, and perhaps save the unknown words for later. Several things I do "sorta" understand are portal hypertension* (PH), nonselective beta-blockers* (such as propranolol [aka Inderal], which I have taken every day since July 1975 for treatment of Essential Tremor -- e.g., healthline.com/health/essen..., ascites*, and very painful inflammation of legs and feet* (see, e.g., healthline.com/health/venou.... ET is fairly common, but it has little to do with treatment of ESLD (that's for another post).
According to the research article, PH could be the cause of death in many cases of ALD. Just as the liver is indispensable to life, so is the heart. PH can cut off blood flow to the heart. I suppose I would have died long ago if not for the effects of daily use of propranolol. Unfortunately, propranolol has turned the tables on me and is lowering my BP below safe levels. Just now, the measure was 99/55. Supposedly, the research drug, aleglitazar, treats PH without the common side effects of the usual nonselective beta-blockers.
I hope all of you are beginning to see the connections. Basically, it has to do with maintaining the continuous, unimpeded flow of blood to and from vital organs.
Next I will tackle PPARγ and TNF receptors. Stay tuned.
The good news is that I don't seem to have cancer or even pre-cancer. I do have to have an MRI every 3 months or so. The facility is kind enough to provide CDs of all tests. Not being a radiologist, I can't actually "read" the "pictures," but it's entertaining to look at them and to be able to see cross-sections of most of my organs, and to compare that with the radiologist's written conclusions.
I find looking into my body icky! Thank gosh for skin is all that I can say lol
What's interesting is statin drug may be helping people with fibrosis. Do people with livers disease normally have high cholesterol? Mine is low and many more I know cholesterol seem to hang a little low. Is it usually higher?
What is interesting is that they are taking liver disease very seriously. For many years a lot of research and publicity has gone into cancer and heart disease, so hopefully the future generation will be more aware and receive better treatment and support.
Now I'm really confused. Brett, the article you posted is dated June 18, 2018, which led me to believe this was a new drug. I just googled "aleglitazar" and came up with this: empr.com/news/more-harm-tha... , dated April 2014. Here's the first paragraph: "According to study data presented at the American College of Cardiology's 63rd Annual Scientific Session, patients treated with aleglitazar (Roche) showed higher rates of heart failure, kidney events, and gastrointestinal (GI) bleeding with no countering cardio benefits. Aleglitazar is a novel study drug with dual action on two subtypes of the PPAR cellular receptor–PPAR gamma that helps glucose regulation and PPAR alpha that helps lipid regulation."
I don't know what all of that means, but I surely would not take any drug with those side effects. I wonder why the Chinese (Taiwanese) are testing it for use in cirrhosis. Maybe we should write to Dr. Ying-Ying Yang (rotfl, tooooo funny) and demand an explanation.
Good grief! This "new" drug has been around the block. I did a bit more searching and found it was also tested for use in treatment of diabetes. All testing in Europe and the U.S. was halted more than 4 years ago. Perhaps Dr. Ding-a-Ling picked up a huge supply on the cheap.
In the meantime, I'll stick with my much-reduced daily portion of propranolol. I think it was developed before I was born (!!!), for use in patients with tachycardia. Sometimes doctors fall all over themselves to try the latest designer drug, using us as guinea pigs. Shameful.
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