New hope

[Livefor]

EurekAlert (press release)

Cancer drugs could potentially treat COPD, Sheffield research finds

há 2 horasEurekAlert (press release)

[2greys]

I believe that this is what you are referring to.

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation.

elifesciences.org/articles/...

Funnily enough I was disusing a related matter just 3 days ago.

healthunlocked.com/blf/post...

[Livefor in reply to 2greys]

Sorry but is not the same

[2greys in reply to Livefor]

It is the source material to that article:

Cancer drugs could potentially treat COPD, Sheffield research finds

University of Sheffield

New research from the University of Sheffield shows a certain class of cancer drugs could be used in the future to treat chronic obstructive pulmonary disease (COPD)

For the first time drugs could be developed to stop the progression of the disease and promote healing within the lungs

COPD makes breathing progressively more difficult for millions of people around the world, including the 1.2 million people living with the disease in the UK

New research has shown the potential for clinically available cancer treatments to treat chronic obstructive pulmonary disease (COPD).

Scientists from the University of Sheffield have been investigating the effect of drugs used to treat a variety of cancers on this inflammatory response; the main driver of lung damage in people living with COPD.

COPD slowly develops over many years - often patients are not aware they have it until their 40s or 50s - and for the 1.2 million people in the UK who have been diagnosed, it makes breathing progressively more difficult.

People living with COPD experience a wide range of symptoms that have an increasing impact on their quality of life, including breathlessness, coughing and frequent chest infections.

The damage to the lungs is driven by inflammation caused by immune cells called neutrophils.

A research team at the University's Department of Infection, Immunity and Cardiovascular Disease screened a library of cancer drugs and identified a number of compounds which accelerate the death of the neutrophil cells and promote healing in the lungs.

The research, funded mainly by the Medical Research Council, discovered that specific cancer drugs inhibit a cell signalling process controlling the death-rate of the harmful neutrophils. The team also discovered that editing the genes that encode the cell signalling in the first place, further decreased inflammation.

Dr Lynne Prince, Russell Fellow at the University of Sheffield, said: "COPD is usually treated with steroids and airway muscle relaxants which ease symptoms, but there is currently no effective treatment clinically available to counteract the damage it does to the lungs.

"Our research now shows that inhibitors of these cell signalling processes, or ErbB kinases, could have therapeutic potential in neutrophilic inflammatory disease.

"The hope of these drugs is that they can clear the damaging cells from the lungs of people living with COPD, preventing any further damage and therefore the progression of the disease for the first time."

Repurposing a clinically available drug has many benefits, said Professor Stephen Renshaw, from the University of Sheffield: "We are in desperate need of a new treatment for COPD, millions of people all over the world live with the disease and it has a massive impact on their quality of life, especially as the disease progresses.

"What is exciting about this research is that these drug compounds are available now, which means if our continued research can effectively find a lead compound to benefit people living with COPD, they are ready to use.

"As neutrophilic inflammation is also central to the progression of other chronic inflammatory diseases such as rheumatoid arthritis, the research has the potential to impact not only people living with COPD.

"Our next step is to find a way to test these drugs in people with COPD to understand how the ErbB kinase signalling process has an effect on lung inflammation and to address any potential side effects."

###

The full study published in eLife is available to download here: elifesciences.org/articles/...

[Livefor in reply to 2greys]

Yes,it's the same sorry

[Hidden in reply to Livefor]

Wow are they looking at human clinical trials now? Can people volunteer? When was this written? doesn't this link the other breakthrough Australia findings.

Great drugs good to go just cannot see when this was written

[2greys in reply to Hidden]

Research Article Oct 15, 2019

[Hidden in reply to 2greys]

Isnt this proof still that the inhibiting of the protein is the key to all of this. Does it say if it has gone to clinical trial yet on humans? I struggled to read the reviewers views

[Hidden in reply to 2greys]

2grey as I am a bit of bambi is this at human clinical trial yet

[2greys in reply to Hidden]

My impression is not quite yet but imminent, even so it will still need to go through trials.

[Hidden in reply to 2greys]

Yes I know but could not make out if clinical trials on humans

[2greys in reply to Hidden]

It looks like it will be human trials because the biggest issue is any side effects. A lot of anti-cancer drugs can be rather brutal.

[Hidden in reply to 2greys]

I heard that from lady I work with but it would be worth it I think but what do I know

[2greys in reply to Hidden]

Some chemotherapy drugs can damage the major organs like the heart and liver, all we can do is hope that it will be safe and effective. It provides the most hope so far.

[Hidden in reply to 2greys]

2grey that we are going to face a double edged sword I would volunteer because I want some hope sure everything will be carefully monitored..

[Hidden in reply to 2greys]

I have found researcher email and have just emailed her regarding potential time frame ect ...hopefully will hear something, be it positive or negative

[babalulu in reply to Hidden]

I would volunteer for this straight away!

[Hidden in reply to babalulu]

Waiting to hear back from university I am hoping good news and not another 10 years time

[Hacienda in reply to Hidden]

You go for Gold Emily, very Proud of you Hun. Along with 2 Gs, valid Research, you can make a Big Difference for all of us. Love n Hugs C. xxxxx

[Hidden in reply to Hacienda]

I am hoping we get a positive response as we need a breakthrough as I know at times I get carried away

[Hacienda in reply to Hidden]

Sometimes it's the only way to go when you get Passionate about something as Vital as this Research. Don't over stress yourself Hun, Take it slowly and give yourself a Break when it gets too much. We are all Here for you. Love as always. C. XXXX

[Hidden in reply to Hacienda]

Got email back they are not at clinical trials just yet but have asked if it was alright to forward my details. This was the media representative. Have not heard from the researcher yet. But that is the update. She could not confirm when trials would begin

[Hacienda in reply to Hidden]

Step by Step Em, You are doing very well to get a Response, The Researcher will come back to you I'm sure. Thanks for keeping us all in the frame Hun. XXX C.

[Hidden in reply to Hacienda]

She got back they are still researching drug before they get to human clinical trial 😥😥 she couldn't give time frame but said if I was interested she would keep me updated

[2greys in reply to Hidden]

The research has to be carried out, as I reiterate, Neutrophils are essential in fighting infections in all parts our bodies. They need to target the drug to the lungs without unduly affecting other body areas. Perhaps nano particle along with magnetic technologies could be utilsed to just target the lungs with the treatment. They obviously do not want to cure one problem and create yet another in the process.

[Hidden in reply to 2greys]

I know they are it's important they conclude all research I understand that completely. I just hoped they were are human clinical trial, that's all.

The targeting that white cell appears to be an answer as a few researchers are looking at that. 2greys would love this in our ife time. I do wonder at times if I am naive

[2greys in reply to Hidden]

Maybe we will see it yet. New drugs can take on average 10 years of trials before they become widely available, but this is re-purposing an already available and approved drug so it will probably arrive quicker, if they can get it to just target the lungs.

[Hidden in reply to 2greys]

I am naive in the ways of research I think see you know 10 years fir drug to be past. I dont understand research

[2greys in reply to Hidden]

Don't be disheartened, this could gain speed quite rapidly, with many advancements in the field of targeted treatments currently being made, that I see it all the time, but do not post as they are not related to lung issues.

[frazwag in reply to 2greys]

at the moment we have at least 4 possible cures being explored and all sound quite plausible and all give us a glimmer of hope even if just one turns out out to be the cure or half cure we are all praying for.

[Hidden in reply to frazwag]

What are the four and and what stage are they at

[frazwag in reply to Hidden]

well i would have to find the articles but am sure 2greys will agree with me .

1. Chinese began clinical trial 2 years ago and claim copd will be cured within 5 years through harvesting and culturing your own stem cells direct on to lungs. already tested on 2 humans candidates with results but news is hard to find

2. a recent article from Denmark i think have created an inhaler which contains collagen and copper (copper peptide i believe similar thing they use in face creams to re elasticate the skin )to help re- elasticated the lungs and hence help with regrowth undergoing tests i believe.

3 vitamin A retinoid was found to regrow lung tissue in in rat and mice as yet no news but were looking at how they could administer the vitimans if it were found to work on humans. natural vitamins A by the way as to much artificial vitamin A is dangerous .

4. as above in start of this thread

all these article do have previous information in the past from years past it just that progress is slow. i will try and gather the links for you.

[Hidden in reply to frazwag]

Aww thank you I think the vitamin a one is no longer viable from what I gather. Would be good to find email addresses so at least we know if still viable progress ect thank you so number 1 now looking at 3 year....

[Hidden in reply to frazwag]

I am sure 2grey will know where these are up to especially the Chinese one well hope its soon 2020 start of something positive

[frazwag in reply to Hidden]

ok i found this link to Chinese trial

eurekalert.org/pub_releases...

[Hidden in reply to frazwag]

Do we know any progress on this it seems research is coming from all angles but guess that's always been the case then

[Kristicats in reply to Hidden]

Did you hear anything yet? Cx