Has anyone read the research done at Melbourne university 'Putting the breaks on lung disease' I am no good at adding website pages. Wondered if anyone had read it
Putting the breaks on lung disease - Lung Conditions C...
Putting the breaks on lung disease
45 Replies
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I have just read this Link that Pete kindly put up for you. I would Volunteer to do the Trials if a UK Research COPD Team Advocated it. Alas probably Too late for me. But what a Great Research to offer for those who would Benefit, Thanks Emily. xxx
• in reply toHacienda
Never say too late. It's taken me months to understand the importance of being positive, You haven't come this far for this disease to win. First lesson you tried to teach me,and got last Sunday. Dont care if I sound naive.
We need to push check follow up on research.
Never too late never Hacienda.
hypercat54• in reply to
To post a link right click on the long address bar at the top and click copy. Go to where you want to post it and click paste, or the ctrl and v buttons together x
• in reply tohypercat54
Thank you
Hacienda• in reply to
I am so happy for your Positive Response Emily, Great that now you sound so more Less naïve, Well Done Hun. Yes I agree we do need to follow up Research. Maybe our Number one King of Research "2Greys" could be our Messenger to Help us understand more. Hugs & Stay as Well as you can Emily . XXXX C.
• in reply toHacienda
Very true we and you stay as well as you can. Not sure I should have but have emailed Melbourne for any update to date, they may not respond but emailed anyway
Hacienda• in reply to
Good for you Emily, Lets hope you get a response and you then can Guide us all. XXXX C.
• in reply toHacienda
Research concludes 2021 December 31 so 2 years, went on university active research page, whilst waiting for a response
2greys• in reply to
Look at you now, go for it girl, the more the merrier. There is so much info out there, one person on their own cannot find it all. Pleased to see you are not taking the condition laying down and trying to do something about it.
• in reply to2greys
No I am not does no good, will have my fed up days but we need to find the research out there. And chase up where they are up to with it. I have even put self forward for clinical trials at brompton. But as I have asthma component may not be accepted, nothing ventured as they say.
• in reply to
Bit of a change here. I remember you as one of the most despondent people I've ever met Emily.
• in reply to
Who says I am not still despondent at times. But why not see where research is up to what's going on out there, how close we are to a breakthrough. Sunday made a difference to me.
Hope drs went ok 😘
• in reply to
Well he didn't look at all well, gaunt even. I came away more worried about him than me.
• in reply to
Oh my, you are funny
• in reply to
Not all the time. 😘
I have looked at my blood test results, from my hospital discharge papers and the normal range for "neutrophils" is 2.0 - 7.5. Mine were 14.5 so a rather high and slightly worrying reading.
The same story is told in a slightly different way here:
copdnewstoday.com/2018/05/1...
• in reply to2greys
So would you say this is promising research 2greys.
2greys• in reply to
It does seem promising, my only question is how are they going to regulate the G-CSF protein level in different people with varying amounts of Neutrophils present. With full blown blood tests, or a simpler method such as diabetics use, a finger prick with a reactive paper strip to monitor their blood sugar. G-CSF protein is still needed, at safe levels, for normal immune response and can't be blocked totally.
I am still searching for more info. It appears that some chemotherapy drugs will lower G-CSF protein and actually given to some chemo recipients during the infusion..
• in reply to2greys
Let us know. I did note they said they couldn't block it all together. A lot of money could be made by pharmaceutical companies here.
2greys• in reply to
That is why I question how they will they regulate it. Some people could end up "jumping out of the frying pan into the fire" if the dose was wrong. Hopefully it might be able to be automated just like the new personal insulin pumps.
• in reply to2greys
I take your point. I imagine regular blood test of sorts to ensure the levels are maintained at a safe levels.
Hi Emily
Please also note that things can and do change. For example my husband is now being told that he can have some valves fitted in his left lung.
He has severe emphysema, hyper inflated lungs and retains carbon dioxide.
About three years ago he was told that he was unable to have valves as the damage in his lungs was too generalised. When I pointed this out to the surgeon he said things had moved on since then and they were now able to perform this procedure.
I asked about the steam ablation as an alternative but was told they do not currently perform it at this hospital.
Hope this reassures you for the future as my husband is much further down the road than you are and armed with knowledge of how to restrict the progression of this disease you should hopefully never get to this point.
Take good care of yourself
Corin
X
• in reply toCorin1950
Thank you for those words of encouragement x
What exciting research! Something to look out for in my next blood test.
I have just read this article, thanks to PMRPete. It is very interesting and really worth reading. I would be very interested to hear what sort of clinical trials they are going to do and if they are going to happen in the UK
• in reply toChristina1941
At present no clinical trials are happening they are in next phase where they will be looking at formulas for treatment, she has emailed me back. But I too am interested to know if anything happening here in Englang
Sandwell hospital has a new consultant who has just started who is looking at starting clinical trials in emphysema but nothing started yet, so my consultant secretary has just said.
Thank You Emily for your Up dates, Keep them Coming Hun. Hugs C. XXXX
It is known that COPD patients are at an increased risk to Lung Cancer other than the smoking link, with researching G-CSF I have come across this, there may be a link here between COPD and Lung Cancer via the G-CSF protein:
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment.
• in reply to2greys
So a strong case potentially to reduce G-CSF, are researchers in England looking at this also?
2greys• in reply to
Not found any English research yet, there are reams of research papers to do with G-CSF. It is linked to so many medical conditions and have been wading through it all today, and typically, getting sidetracked by what is a fascinating subject. The G-CSF protein is super important as Neutrophils will make up over half of the white blood cells that attack infections and also the quickest to arrive on the scene of an infection.
• in reply to2greys
Wow 2greys, no wonder research is taking so long to manifest into reality. Think Japan is also doing research. I will ask brompton tomorrow as I am there
2greys• in reply to
In actual fact I have just come across a report from 2011, this research has been going on for a lot longer than first thought.
Neutrophil Elastase Inhibitors.
ncbi.nlm.nih.gov/pmc/articl...
At the end of that report it says:
5. Expert Opinion
Significant progress has been made toward our understanding of the key biochemical and cellular events associated with COPD. The multiple pathogenic mechanisms involved in the disorder are currently better clarified, and the relative significance and contribution of the mediators involved are better defined, than in the past. Nevertheless, our knowledge regarding the inter-relationships among the various processes and mediators and how they impact the initiation and progression of the disorder, is still incomplete. The problem is further compounded by the unavailability of suitable validated biomarkers (112) for assessing the efficacy of potential therapeutic interventions. The complexity of COPD suggests that effective therapeutic interventions may require the administration of more than one agent such as, for instance, an HNE or MMP-12 inhibitor with an anti-inflammatory agent such as a phosphodiesterase-4 inhibitor, or a dual function agent capable of disrupting the cycle of proteolysis, apoptosis, inflammation and oxidative stress (113–116) (Figure 1). This is a fast moving area of research that, despite the challenges that lie ahead, will continue to illuminate our understanding of the disorder, as well as identify new therapeutic targets. Exploration of these targets is likely to lead to the emergence of disease-modifying therapeutics for COPD in the not too distant future.
In order to minimize damage to tissues, there are few inhibitors of neutrophil elastase. One group of inhibitors are the Serpins (Serine Protease Inhibitors). Neutrophil elastase has been shown to interact with Alpha 2-antiplasmin, which belongs to the Serpin family of proteins.
en.wikipedia.org/wiki/Neutr...
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Serpin
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Alpha 2-antiplasmin
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