Hey all! This is my first post😌I have been diagnosed with alpha-1 antitrypsin deficiency, COPD with emphysema, bronchiecstasis, and factor v Leiden deficiency! I have had bilateral blood clots in my lungs, arms and legs. Now I was told I have mac pneumonia from mycobacterium avium intercellular complex, have been on treatment now for 6 months. My recent spirometer showed a decline in my Fev from 2.28 to 1.76. I have been trying to work but was told I needed to quit my job- working is making me too tired and I have no reserve . Has this happened to anyone else? Is this the normal progression of these diseases ?