Hi all, I'm new here. I found this site by googling "Seretide muscle cramps". After two or three years of inhaling Seretide 250/25 twice a day it has finally occurred to me it may be causing my awful leg and foot cramps at night. I am also much huskier than I used to be (frustrating for a singer) and sometimes I get cramps in my hands. It's like the tendons sieze up. Therefore I am going to discontinue Seretide and see what happens. I am not asthmatic; I just have a rare lung disease which affects my lung tissue and reduces my O2 diffusion capacity. My airways are not as affected so I don't feel any noticeable difference if I take Seretide or not. If there is any improvement in my symptoms I will be very relieved as the night cramps have been pretty intolerable. I'll let you know the outcome.