And Albuterol. I have SOB on them, off them. I have been on/off the Dulera since Jan. I stopped taking in the past when this all began in Jan because I did not notice a difference. I started again a couple weeks ago per my GP, and don't feel much different. On Spiriva almost a month, not much difference. Maybe after I first use it, then it's like I never took it. Maybe the same could be said for Dulera. Once lasts 24 hr, one 12 hr. I just don't know sometimes. My SOB already out of proportion to my PFT's not to mention the meds feel like they do very little. Prior to all this I rarely used Albuterol, and when I did it worked wonders. Now I use two meds daily and it's like the difference is so small, if at all.