did anyone see this on the email from Asthma & Lung UK?

[girl_DJ_b]

I’m intrigued by this!

[Ergendl]

That sounds exciting. And no, I hadn't noticed it.

[Swizzy]

This is probably brensocatib which has been going through trials. It is the first drug developed solely for bronch. It has proved so succesful that many who took it on the trial remained on it. I spoke to my consultant about it three weeks ago. She said that I would certainly qualify to take it. They are waiting for it to go through the processes. NICE, funding etc. So fingers crossed. If this one finally gets to us it will be the first in forty years of taking part in trials of drugs which never made it.

[girl_DJ_b in reply to Swizzy]

Wowee that’s potentially very exciting!

[Patk1 in reply to Swizzy]

Yes I imagine so,too,Swizzy.i like to check in on what he's doing.im on benrazilumab for severe eosinophilic asthma,and it has a positive impact on my bronchiectasis too

[Swizzy in reply to Patk1]

That's interesting

[Patk1 in reply to Swizzy]

Yes.brand name is Fasenra.i think it's the impact it has on inflammation that's helping bronchiectasis.trouble is it's ea 8wks but for me it wears off after 6wks,takes nr a wk to work so only getting 5wks benefit of ea 8 week cycle. its disheartening to slip backwards.but 5 wks is better than none.

[Swizzy in reply to Patk1]

Maybe the bronsicotab will work better for your bronch as brenzalizumab is really an asthma drug. Hope on the horizen.

[Patk1 in reply to Swizzy]

It is but as well as depleting eosinophils,it targets inflammatory pathway which seems to have helped - not producing as much mucous from bronch,as well as asthmatic mucous reduced.another huge benefit of,except during wear off or on a bad day,my airway collapses( both breathing in + out were v severe at >90%)are much reduced >]] that said,I'll certainly be requesting brensocatib whn it's available,living with permanently collapsed lower lobe of lung due to bronch. It's marvellous what advances are being made with biologics and inflammation in very many diseases x

[Swizzy in reply to Patk1]

I do hope that it goes on.helping you and that the new type of drug helps us all. My consultant in the 1970s talked a lot about eosinophils and inflammation in bronch. He had to fund his research himself because everybody thought that he was crazy.It is great that his work has been taken up by others and that he was proved right. He is still researching in Bham but doesn't see patients today.

[TeachKat in reply to Patk1]

I’m also on benralizumab, for severe eosinophilic asthma and also struggle for the last 2 or 3 weeks of the 8 week cycle. It’s amazing for 6 weeks or so, but the last two weeks are difficult.

[Patk1 in reply to TeachKat]

I think the wear off wks are harder,having been better for 5wks :>(

[Eccles44 in reply to Patk1]

Hi Patk1 I'm on this too for eosphinilic asthma and agree it's helped my bronchiectasis on the whole too. I was interested to read your comment about it wearing off before the next injection. I've wondered about this too. Sometimes I've wondered if my symptoms have increased towards the end of the cycle and then I've dismissed it. But perhaps it's not my imagination then.

[Patk1 in reply to Eccles44]

Gd to hear yr reaping the benefit too.i find as it wears off,symptoms are tough after being improved for those 5wks.do tell yr biologics nurse x

[Shawshank62 in reply to Patk1]

I too am on fasenra and have the very same; 5-6 good weeks. I’m learning to plan around it for holidays etc. I wonder if you can take both drugs together?

[Patk1 in reply to Shawshank62]

I'm going to tell my biologic nurse/ asthma specialist how many of us r finding it wears off at same point.yes let's hope so x

[Alberta56]

Dr. James Chalmers talks regularly on ELF (European Lung Foundation) conferences. He sounds a lovely man. I'll post when the next conference is due, since lovely Cofdrop, who used to alert us to these events, is sadly no longer with us.

[Osha]

Very intriguing. I’ve taken note of professors name and product and will ask my consultant about it when I see him in may

[Patk1 in reply to Osha]

You can read up on his work and research if I put his name in Google.i can't remember if it's university of Edinburgh or Dundee. I think they're oh phase 3 of trials now with v promising results

[Manuker in reply to Patk1]

It's University of Dundee.

[PaulineHM]

Hello,

Prof Chalmers is always working away on bronchiectasis research issues and projects. Always encouraging others to do the same.

I am sure there will be something available which will help fellow patients along in the near future.

Traditionally lung disease hasn’t had the research available it deserves but I think over recent years that has changed a little bit.

Since I have been with the patient engagement teams with one of the big pharmaceuticals I have worked with them on 2 research design trials, one for COPD and one for Asthma.

Things do change and improve, not perhaps for us but surely for those who follow in our footsteps.

Go well

Pauline

[HerLadyship]

Hadn't seen it but definitely good news

[AsthmaandLung Administrator]

Hi girl_DJ_b

Thank you for posting this. Here is some further information from our Research Operations Colleagues in regards to Brensocatib, including the comments from Dr Chalmers.

Brensocatib has been tested in people with bronchiectasis in clinical trials, which found that the drug made a real improvement to participants’ lung health. The drug is now due to go through a variety of approval processes (i.e. NICE) and we can expect it to be in people’s hands by 2026. James explains:

“Today, there is no approved treatment for bronchiectasis and there remains an urgent need for a therapy that can reduce exacerbations. Brensocatib would be the first treatment in its class and could offer a completely new approach to managing this difficult-to-treat patient population, heralding a new era in clinical management of bronchiectasis."

This new drug could also transform the lives of people with other lung conditions too. Once the drug is approved for bronchiectasis, it could be tested to see if it can help to treat other lung conditions like asthma, COPD and IPF. Given that 12 million people in the UK will get a lung condition during their lifetime, this new drug – and James’s research – could make a huge difference to millions of people who struggle to breathe.

Helpline Team

[girl_DJ_b in reply to AsthmaandLung]

Brilliant news!!