COPD stem cell trials ---latest

[pasquino]

latest result from stem cell trials per state

clinicaltrials.gov/ct2/resu...

some studies are finished and the results are encouraging in my opinion .

Pasquino

[garibaldon]

Clicked on the link. I ll take your word for it cos they might just as well as been written in Aribic for all I understood them

[Hidden]

Whilst not wanting to seem discouraging, my own opinion is you can’t draw any meaningful conclusions from the data provided. Of the 4 studies listed, 3 were observational - so no placebo or control groups - and one was withdrawn before completion. One of the 3 studies that completed wasn’t actually for PRP therapy. That then leaves us with two. One of those was completed in 2016 and published in 2017, so is fairly out of date at this point, and had terrible data return for some of the primary outcome measures, so can’t be considered conclusive even for an observational study. Which leaves the one that was completed in 2019 and published this year. I’d agree that the data provided does look encouraging, but other than fev1 (which showed only very, very modest improvement and I wouldn’t be surprised to find wasn’t considered statistically relevant as a result) most of the measures assessed were subjective outcomes like quality of life and breathlessness surveys. Generally speaking, research data summaries are not conclusive, you need the paper’s analytical context to know what it actually means for treatment and any future research. Without forgetting the study was also purely observational, so even if the results were deemed positive, there would still need to be further studies done to say objectively it’s a realistic prospect for a working, widespread treatment.

[goathead53 in reply to Hidden]

i have recently been diagnosed with emphysema. have never smoked in my life.after watching my father die from it ,he was a smoker. have been prescribed braltus but dont think its helping. i have researched so much and learned that nebulising with glutathione is supposed to have marvellous results, has anyone out there tried this?

i am going to germany in 2 weeks for stem cell therapy,

[Patk1 in reply to goathead53]

Welcome to the forum goathead53 x

[pasquino in reply to goathead53]

Thanks for the information and I wish you all the best for your health.

What I would like to know is if you will undergo a therapy with Stemm Cello or a therapy with Platelet;

As far as I know in the EU stem cell treatments are prohibited ... what happens, even here in the UK, is that many clinics sell a therapy made with Platelet Cells (also stem cells) as Stemm Cell Therapy. link that will clarify your ideas about this therapy.

Unlike stem cell therapy (not allowed), this therapy is tolerated as it is carried out with cells from the same patient, so there is no risk of rejection, obviously the benefits seem to exist in terms of less inflammation and improvement in capacity. respiratory. .

Obviously the results are not what one would expect from ultra-potent stem cell therapy not yet permitted but truly reconstructive when authorized.

Having said that, pay attention to what they ask you in Germany, because in the USA a therapy with Platelet cells costs no more than 7/9 K pounds (take a look at the links), here in the UK they even asked me for 28K + 3K for tests, my opinion is that they are taking advantage of the situation also as a consequence of the effects deriving from the Covid pandemic.

However do your research and please, in the common interest, update us on the results.

I thank you in advance

Pasquino

copdnewstoday.com/2021/07/1...

bioinformant.com/cost-of-st...

[goathead53 in reply to pasquino]

hi i researched many places the one in columbia run out of the us. the one in Russia swiss medica, had consultation with each, both said they couldnt do it due to the prostrate cancer i had radiotherapy for 3 and half years ago. i have been in remission ever since, get psa checked every 6 months.however i came across dc blocks clinic in bavaria. where they use cells from a herd of sheep they have up the mountain, they have been involved in this for 60 years . I have had three consultations with mr d block and has guaranteed me that the treatment will not start the cancer also told me he has never had a problem with rejection,

please look at his website and tell me what you think:

as i previously stated i am booked.

in from the 21st to 26th Nov

regards steve

[pasquino in reply to goathead53]

Sorry ...You forgot the link....😁

[pasquino in reply to goathead53]

Hi,sorry sorry the delay

I took a look at the site and also the comments from other sites.

I have not found anything that could suggest a scam but at the same time nothing that could suggest a specific improvement of some defined physical problem such as COPD / Emphysema

What I understand is that using his system results in an overall improvement in health which could in theory, at least for us, alleviate breathing problems; however I do not see any reference to the respiratory system but only assurances of a rediscovered "balance"

That this treatment can fight inflammation of the lungs and therefore give us an improvement in breathing is possible, but then we must evaluate the cost / benefit ratio.

I don't know how much it will cost you, but obtaining a decrease in lung inflammation and consequently a modest improvement in FEV can be obtained in one of the many clinics in the USA at a cost of about 2/3 K pounds + transfer for a short stay.

centersforrespiratoryhealth...

Therefore if the cost is similar, it might be worth trying, also because it seems that it is possible to obtain at least one physical revitalization which is always welcome, but still, it depends on how much you are willing to spend.

Best wishes,

[goathead53 in reply to pasquino]

Hi the cost is about 10 k that includes the 5 night stay full board in a 5 star hotel, the guy told me the cells will be taken from the donors lungs, as well as the overall improvement in all cells. that these should kick off the healing in the lungs. ie like for like, i hope so , but i will find out in a couple of weeks.i nebulised glutathione for the first time last night, i felt like it opened up my lungs as well as my sinuses, but early days.

i wonder if i should continue with the braltas as the doc prescribed, as i suppose there could some issues, any thoughts.

thanks so much for your input much appreciated, after all we are all seeking the same goal!

regards steve

[Hidden in reply to goathead53]

Welcome to the boards. I’m not personally aware of anyone here nebulising glutathione; it doesn’t mean there isn’t, as we have thousands of members. The support for doing so remains anecdotal, though, and actually goes against much of the existing evidence: there have been multiple studies around nebbed GSH over the last 20 years, with the most recent ones all concluding that whilst GSH is significantly deficient in many lung conditions - not just COPD - direct replacement via even nebulising is not beneficial due to a number of other factors. They’ve determined that the most likely benefit would come from somehow rebooting and optimising the body’s ability to produce natural GSH, which is why glutathione is not a recognised therapeutic avenue, and further work on employing it as a treatment for those with a variety of lung diseases almost entirely stopped around 2016 or so. They ultimately found that direct GSH supplementation by any means has little to no bearing on GSH levels, and often results in increased production of other elements that unbalance the epthilial lung fluid (ELF) even further and can additionally decrease natural production of GSH, thus counteracting the intended action. Increasing GSH also has no bearing on lung function, with decline continuing even in the presence of more normal levels of GSH. What they have determined, though, is that supplementing the precursor building blocks of GSH production can be helpful, with NAC being considered as a potential avenue to do so as it contains cysteine, which is one of the three precursors vital for GSH production. NAC as a therapeutic agent in lung disease is becoming increasingly valued above other mucolytics such as carbocysteine, in part because of the antioxidant angle.

They’re very heavy going to read, but if you want to look into the studies in detail, then a search for ‘glutathione AND copd’ on core.ac.uk will bring up dozens of relevant papers. The main ones I would draw your attention to are:

ncbi.nlm.nih.gov/pmc/articl...

core.ac.uk/reader/55712375

core.ac.uk/reader/188139888

core.ac.uk/reader/267306539

[goathead53 in reply to Hidden]

thanks so much for the information

[pasquino in reply to Hidden]

Thanks for the informations,

In reality I was also referring to Platelet based Therapy which obviously does not aim to regenerate the lungs but to be effective as a limitation of inflammation and consequently improvement of lung capacity.

As far as I know it is an Autologous therapy without serious side effects that must be carried out once or twice to obtain an effective improvement.

Here in the UK there is only one center for the moment, in a luxurious clinic on Harley St; the doctor I met did not talk to me much about the characteristics of the treatment, but only that it would be one or more injections to be repeated perhaps after six months, therefore more or less what we are talking about in the USA; the only difference was the price: I was charged 25k pounds + 3K pounds for "tests" ... obviously I refused also because in reality they did not offer any guarantee on the treatment but only vague hopes and possibilities.

Thanks anyway for the always valuable information in these cases.

Pasquino

[Hidden in reply to pasquino]

My reply was literally an analysis of the data you provided as evidence of autologous PRP being beneficial: the data in the studies you linked to doesn’t currently show it is beneficial. There was no statistically meaningful improvement in lung capacity, because there was no significant improvement in spirometry values in the one study of the 3 that had a good dataset. Even in the US where it is more readily available via private clinics as a naturopathic therapy, it’s not currently an FDA approved treatment for any disease. In time we may find it does have a place in managing COPD, but as things stand it’s not been studied to a satisfactory extent to draw any conclusions one way or the other.

[pasquino in reply to Hidden]

Thanks,

Here is an abstract showing some decent improvements ..

Comparing after and before stem cell treatment, we found improvement of patient's symptoms and dyspnoea level by the CAT score, mMRC, and SGRQ. In addition, his exertion capacity improved, with 6MWTs increasing from 441 to 546 m. He did not have any acute exacerbation during one-year follow-up. The inflammation in the lumen decreased after one year of stem cell treatment. The overall results suggest that the patient's improvement is related to the stem cell therapy. However, more well-designed and long-term trials are necessary to prove about the efficacy of stem cell therapy.

onlinelibrary.wiley.com/doi...

I understand that is not the perfect solution , but in line of principle if such treatment could be obtained for , say, 1500/2000 gbp it could be worth a try , accepting of course the limited but welcomed improvement.

Thanks again

Pasquino

[Hidden in reply to pasquino]

Pasquino, that’s a single case study of a completely different therapy to PRP. It’s a report on a patient that received ADSC (adipose-derived stem cell therapy). It’s also not even remotely conclusive as to the overall, long term, sustained benefit of ADSC. It does reinforce that these are areas for further research, but that’s it. I don’t want you to think I’m being negative or difficult, it’s just even if these treatments are ultimately proven to be helpful, we are years from being close to that due to the need for thorough, randomised, double blind studies with concrete, quantifiable outcomes. Other than an increase in the distance covered in his 6 minute walking test, basis of benefit to the chap in the case report was otherwise entirely subjective in the form of quality of life questionnaires and his perception of his breathlessness. These things are completely relevant, but hardly definitive.

[pasquino in reply to Hidden]

knew but thanks anyway..

[Daisychains01 in reply to Hidden]

But just because it's not part of mainstream medicine doesn't mean it isn't being done, and that one shouldn't try it. PRP has helped MANY for many different problems. There are cases of people who have tried stem cell therapy for lung diseases and have reported good results. BUT, if you listen to most doctors, they will tell you it's quackery.

[pasquino in reply to Daisychains01]

As far as I am concerned I will be happy to invest a modest sum 1500/2000 even for a temporary relief....(1 year or so).. I only do not know who is a reliable and honest organization in uk.(London)

If you can give me some clues I will appreciate.

Thanks

[Daisychains01 in reply to pasquino]

I'm sorry, I'm in the US. I can tell you that here PRP is done by Chiropractors or functional medicine doctors. Not the "traditional" mainstream docs.

[goathead53]

i cant copy and paste, only have chromebook, just google Dr Siegfried Block live cell therapy

[pasquino in reply to goathead53]

I will, thanks.

[goathead53 in reply to pasquino]

thanks please let me know your thoughts

[Daisychains01]

I saw another study that showed damage reversal. I think this is encouraging news. You can do PRP on your own. Unfortunately because insurance doesn't cover, you have to pay for your own. I also don't trust the ones at the top anymore. Some of these studies are directed in the way they want them to go. I've seen this with another drug, and with natural supplements. They do the studies so that the participants are getting too high a dose, and then deemed unsafe, or the opposite, then they say they don't have any benefits. They do them to show us that they are doing something. But big pharma wins all the time.