New research has identified potential treatment that could improve the human immune system’s ability to search out and destroy cancer cells within the body. Scientists have identified a way to restrict the activity of a group of cells which regulate the immune system, which in turn can unleash other immune cells to attack tumours in cancer patients.
“A patient’s immune system is more than able to detect and remove cancer cells and immunotherapy has recently emerged as a novel therapy for many different types of cancers,” explained Nullin Divecha, Professor of Cell Signalling at the University of Southampton who led the study. “However, cancer cells can generate a microenvironment within the tumour that stops the immune system from working thereby limiting the general use and success of immunotherapy,” he continued.
Detection and removal of cancer cells by the immune system is carried out in part by a group of cells called Teffector cells (Teffs). How well Teff cells work in detecting and removing cancer cells is in part dictated by other T cells called T-regulatory cells, or Tregs for short. Tregs physically interact with the Teff cells and produce molecules which reduce the ability of the Teff cells to work properly.
Prof Divecha added, “Tregs carry out an important function in the human body because without them, the immune system can run out of control and attack normal cells of the body. However, in cancer patients we need to give the Teff cells more freedom to carry out their job.”
southampton.ac.uk/news/2021...
Proceedings of the National Academy of Sciences. Research Paper:
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