Researchers show that certain antibiotics can prevent the entry of SARS-CoV-2 into cells.

[2greys]

The Drug Design and Molecular Topology Unit group of the University of Valencia has shown that certain macrolide antibiotics (used in respiratory tract infections), including clarithromycin and azithromycin, can prevent the entry of SARS-CoV -2 in cells. The study, led by Professor of Physical Chemistry Jorge Gálvez, has been published in the prestigious North American Journal of Chemical Information and Modeling.J. Galvez and his research team

The group already pioneered an article in March 2020, proposing such antibiotics as drugs that could be targeted to treat COVID-19. However, this prediction was only based on theoretical computational calculations. The method was based on molecular topology, a part of mathematical chemistry that deals with the algebraic description of chemical compounds, which allows them to be easily characterised.

Now, in collaboration with researchers from the National Center for Biotechnology (CSIC), they have shown with their study that these antibiotics are capable of preventing the entry of the virus in vitro by deactivating the well-known spike protein.

ruvid.org/ri-world/research...

Journal of Chemical Information and Modelling. Research Paper:

pubs.acs.org/doi/10.1021/ac...

[sassy59]

Wow, great news. Xxxx

[cofdrop-UK]

Excellent post 2g. Shame I cannot tolerate macrolides but preferable to covid.

Thank you.

Cx

[Hidden]

Very interesting

[2greys]

Not yet, if they do, I will direct them to take up any argument with the researchers at the University of Valencia, I am not a member of that faculty either. 🤪

[hypercat54 in reply to 2greys]

😁😂🤣 x

[Oshgosh in reply to 2greys]

🥂💥💥💥

[Oshgosh]

That’s really interesting and potentially encouraging.I e been on Azithromycin for over 2 years.thanks for that.

[Jandm]

My consultant told me about that theory last year, so that’s fantastic news 😃

[santisuk]

Same as Oshgosh. 3 x a week prophylactic dose for my bronchX. No infections for nearly 2 years. I love my azith! Hope the research doesn't lead to a sudden shortage. I'd better stock up.

Coincidentally my pharmacist told me yesterday that my other bronchx drug - the mucolytic NAC acetylcysteine - is making a showing as a potential Covid symptom reliever in consort with hydrocloxychloroquin. I was buying 4 months supply of that anyway! I had told him in response that I'd read that azith was being rumoured as a helper too (based on something I'd seen a month back.

Now I write that I can't recall whether it's the azith or the acetylcysteine that goes with hydro-thingy.

[ElsaC]

Good to know.

[Patk1]

Unfortunately I still got covid last mar/Apr whilst on azithromycin 250mg x2 daily