Most People Mount a Strong Antibody R... - Lung Conditions C...

Lung Conditions Community Forum

56,238 members66,864 posts

Most People Mount a Strong Antibody Response to SARS-CoV-2 That Does Not Decline Rapidly.

2greys profile image
5 Replies

The vast majority of individuals infected with mild-to-moderate COVID 19 mount a robust antibody response that is relatively stable for at least five months, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 28, in the journal Science. Additionally, the research team found that this antibody response correlates with the body’s ability to neutralize (kill) SARS-CoV-2, the virus that causes COVID-19.

“While some reports have come out saying antibodies to this virus go away quickly, we have found just the opposite – that more than 90 percent of people who were mildly or moderately ill produce an antibody response strong enough to neutralize the virus, and the response is maintained for many months,” said Florian Krammer, PhD, Professor of Vaccinology at the Icahn School of Medicine at Mount Sinai and a senior author of the paper. “Uncovering the robustness of the antibody response to SARS-CoV-2, including its longevity and neutralizing effects, is critically important to enabling us to effectively monitor seroprevalence in communities and to determining the duration and levels of antibody that protect us from reinfection. This is essential for effective vaccine development.”

Study findings are based on a dataset of 30,082 individuals, who were screened within the Mount Sinai Health System between March and October, 2020. The antibody test used in this research—an enzyme-linked immunosorbent assay (ELISA)—is based on the virus’s telltale spike protein that contains the machinery that enables it to attach and gain entry into our cells. The ELISA assay was developed, validated, and launched at Mount Sinai by a team of internationally renowned researchers and clinicians. The Mount Sinai antibody test detects the presence or absence of antibodies to SARS-CoV-2 and, importantly, is capable of measuring the titer (level) of antibodies an individual has. The high sensitivity and specificity of this test—meaning that a false negative or false positive is highly unlikely—allowed it to be among the first to receive emergency use authorization from New York State and the U.S. Food and Drug Administration.

mountsinai.org/about/newsro...

Sciencemag. The research paper:

science.sciencemag.org/cont...

Written by
2greys profile image
2greys
To view profiles and participate in discussions please or .
Read more about...
5 Replies
HungryHufflepuff profile image
HungryHufflepuff

So many conflicting and contradictory reports, but hopefully this one is correct.

in reply toHungryHufflepuff

it certainly does depend on what article you read HH and for sure all studies may well be accurate so best to keep an open mind.

In addition we all need to fully understand the information being provided so that we do not confuse information;

-- The above study involved 72K people with mild to moderate symptoms and were being tested for COV-2 antibodies.

The UK study involved 360K from all age groups across England study for Covid 19 antibodies ... stating

" Antibody response over time varies depending on a person’s age and symptoms "

gov.uk/government/news/larg...

There are explanations on you tube about the difference between COV-2 and covid19 ; here is one short video:

youtube.com/watch?v=eqZFUIm...

.

2greys profile image
2greys in reply to

It can also depend on which serology tests are used, not all are equally acurate, there is also more than one specific antibody. I tend not to worry too much about antibodies alone. In my view B-cells and T-cells are more important and the consensus is that these are lasting for much a longer term.

in reply to2greys

I tend to pay more mind to what is happening in UK and how its affecting things here, the main thing being we all need to continue to be extra cautious whatever environment we are living.

B and T cells - everyone's body has them unless they have a really shot immune system where the system is compromised, which is why those already with immune system vulnerability are more at risk with covid19

en.wikipedia.org/wiki/Lymph....

2greys profile image
2greys in reply to

Unfortunately, British is not always best nor fastest. The German Pfizer vaccine may be ready before Oxford-AstraZeneca. The AstraZeneca one would be my personal choice because it has shown a robust T-cell response as well as with a wide age range.

pmlive.com/pharma_news/pfiz...

Not what you're looking for?

You may also like...

Could SARS-CoV-2 evolve resistance to COVID-19 vaccines?

Similar to bacteria evolving resistance to antibiotics, viruses can evolve resistance to vaccines,...
2greys profile image

Researchers show that certain antibiotics can prevent the entry of SARS-CoV-2 into cells.

The Drug Design and Molecular Topology Unit group of the University of Valencia has shown that...
2greys profile image

Pfizer BioNTech vaccine likely to be effective against B1.1.7 strain of SARS-CoV-2.

The preliminary data, which have yet to be to peer-reviewed and relate to only a small number of...
2greys profile image

Discovery of a druggable pocket in the SARS-CoV-2 Spike protein could stop virus in its tracks.

A druggable pocket in the SARS-CoV-2 Spike protein that could be used to stop the virus from...
2greys profile image

Immunological memory after SARS-CoV-2 infection recovery. *The welcome news we have been waiting for*

Until now, it was unclear whether a survived SARS-CoV-2 infection or COVID-19 leads to a persistent...
2greys profile image

Moderation team

See all
AsthmaandLung profile image
AsthmaandLungAdministrator
Claire_ALUK profile image
Claire_ALUKAdministrator
moderator_AandLUK profile image
moderator_AandLUKAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.