Investigators at Wake Forest School of Medicine, part of Wake Forest Baptist Health, have identified a set of new genetic markers that could potentially lead to new personalized treatments for lung cancer.
The study appears online in Cancer Research, a journal of the American Association for Cancer Research.
This study was built on a previous discovery by the precision oncology team at Wake Forest Baptist's Comprehensive Cancer Center, directed by Wei Zhang, Ph.D., professor of cancer biology at Wake Forest School of Medicine and a co-corresponding author of this study.
Using DNA sequencing technologies, Zhang's team found that tumors with mutated KMT2 genes, a family of proteins, exhibit a feature of genetic instability with numerous mutations in the genome.
"These findings suggest that KMT2 genes may be required for the repair of DNA damages caused by carcinogen exposure such as excess tobacco smoking.
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