Hi everyone,
I have G6PD deficiency and although not life-threatening as long as I stay clear of the list of substances that can cause an allergic reaction, I have recently been reading about some studies that highlight a concerning correlation between Coronavirus and people with the same condition as myself.
I have posted my findings below and wanted to know if there are any other G6PDd patients out there or anyone else aware of this relationship between G6PDd and Covid (apparently, there are 400 million G6PDd patients worldwide but most of the doctors I have spoken to seem to know very little about the correlation).
I have also posted links to the web articles and medical journals that the information has been drawn from, containing additional details.
Here is the info I have uncovered so far:
"There is evidence to suggest an association between G6PD deficiency and increased susceptibility to, and severity of illness with, COVID-19 infection."
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"Is there any evidence to support a correlation or causal relationship between G6PD deficiency and COVID-19 infection susceptibility or severity of illness? Oxidative stress is known to increase viral proliferation and virulence. A study published in 2008 looked at another human coronavirus, HCoV229E, and its effect on G6PD-deficient cells. The investigators found that G6PD-deficient cells were more susceptible to HCoV229E infection and cell death. Addition of an antioxidant decreased this susceptibility. Two researchers from Estonia released a manuscript preprint last week in which they conclude that COVID-19 stimulates a pro-inflammatory systemic response, which is pro-oxidant, and inhibits anti-inflammatory (anti-oxidant) response. This results in an imbalance/overproduction of free oxygen radicals, which further sustains the systemic inflammatory response syndrome. The situation would be made worse in patients with G6PD deficiency, in which cells aren't as able to neutralize these free oxygen radicals."
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"Both G6PDd and SARS-CoV-2 compromise the AO system through the same pathways rendering G6PDd the Achilles' heel for COVID-19. Thus, the evolutionary antimalarial advantage of the G6PDd cohort can be a disadvantage against SARS-CoV-2."
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"Glucose-6-phosphate dehydrogenase (G6PD) deficient individuals may experience a hemolytic crisis after being exposed to oxidants or infection. Individuals with G6PD deficiency are more susceptible to coronavirus infection than individuals with normally functioning G6PD. An altered immune response to viral infections is found in individuals with G6PD deficiency. Evidence indicates that G6PD deficiency is a predisposing factor of COVID-19."
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"Preclinical studies using G6PD deficient (G6PDd) cells infected with human coronavirus (hCoV), show impaired cellular responses, viral proliferation and worsening oxidative damage."
"Retrospective chart review in hospitalized patients with COVID19 pneumonia needing supplemental oxygen shows differences between the two groups (Normal and G6PDd) in hematological indices; the G6PDdgroup demonstrated prolonged PaO2/FiO2 ratio, and longer days on mechanical ventilation indicating the severity of the pneumonia."
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