The search for a gene therapy to reverse pulmonary fibrosis associated with ageing.

[2greys]

Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure and that is associated with certain mutations or advanced age. The Telomeres and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) had previously developed an effective therapy for mice with fibrosis caused by genetic defects. Now they show that the same therapy can successfully be used to treat mice with age-related fibrosis.

“With respect to humans, our results indicate that it may be possible to devise a treatment to prevent the development of pulmonary fibrosis associated with ageing,” says Maria Blasco, principal investigator of the study that is published in The Journal of Cell Biology.

cnio.es/en/news/publication...

The Journal of Cell Biology:

rupress.org/jcb/article/219...