The combination of four drugs at low doses is more effective and less toxic in the treatment of a lung cancer type

[2greys]

Inhibit the specific activity of a protein affected by a mutation using high doses of a drug is the usual treatment for many cancers. Despite in the first instance this strategy is effective, leads to treatment resistance development by tumor cells through the appearance of secondary mutations, which enhance alternative growth pathways, and allow cells to avoid the effect of the drug. This is the case of non-small cell lung cancer (NSCLC), caused by mutations in the EGFR receptor, in which treatment with EGFR inhibitors leads to resistance.

bioengineer.org/the-combina...