(...I subscribe to Medscape and believe I've posted articles here before; here's another that might peak your interest....)
medscape.com/viewarticle/88...
(segment)
"...In essence, this study clearly showed that our approach to a population that pulmonologists might not see—patients with low-level symptomatology or to whom we might say that the benefits of relieving symptoms don't outweigh the hassle of taking a medication—was clearly incorrect. By adding tiotropium, these patients were able to improve lung function and quality of life.
The question remains as to whether this drug actually alters the natural history and trajectory of COPD, or whether this is just frame shifting and delaying what is going to happen inevitably..."
(...more at site...)