The lancet

thelancet.com/journals/lanr...

Some interesting stuff about COPD and E-cigs which might be helpful.

Cal2 x

[Jjude]

can you name the title of the article, because my head is a tad fuzzy this morning and I can't find it. would love to have a read xx

[Hidden in reply to Jjude]

There are a couple of detailed letters about treatment of copd along with the authors reply. There is also an article about the use of E-cigs. If you look down the list of things in it they are quite near the bottom. x

[Hidden in reply to Hidden]

Hi done a copy for you. x

Correspondence

A new chapter in therapy for cystic fibrosis

COPD management: need for more consensus

COPD management: need for more consensus

COPD management: need for more consensus – Authors' reply

[Minushabens]

Is there any clear (or clear-ish) evidence yet about the effect of breathing in second-hand e-cig vapour? Having grown up as an asthmatic having to cope with smoky pubs, clubs, football grounds, etc., the smoking ban created an incredible improvement in my quality of life & ability to enjoy social settings.

I've noticed though now that lots of places like pubs, stadia, etc. seem quite happy to allow e-cigs & I am back to breathing in other people's fumes. Now part of me objects per se to that but I am worried as well, particuarly as my lung issues are much worse now than back then, if that is creating a risk.

[Hidden in reply to Minushabens]

I don't think so Min. But have a read of the article. I still maintain though that e-cigging is much better than smoking if you can't manage to give up without help. x

[Minushabens in reply to Hidden]

It definitely is & I can see the advantage...& the noxiousness (& obnoxiousness!!) of the fumes is far less. I think I'd stop worrying if I thought it was safe to breath in because in truth I'm breathing in things on a daily basis that are probably causing far more grief in there, but I think I've become hyper-sensitive these days!!

[Jjude]

Thanks found it xx

[casper99]

Hi coughalot, thank for the info but, I can't find the article on Ecigs, I guess it was not good news about them? x

[Jjude in reply to casper99]

I had to register (free) still couldn't find it but twitter did and took me straight to it. Lancet Respiratory. about 14 tweets down

[Hidden]

E-cigs from the lancet. Sorry folks this bit didn't come over with the link. It is USA research but they are usually ahead of us anyway.

Sorry it is a bit long x

One of the most hotly debated topics over the past year has been the use of electronic cigarettes (e-cigarettes), driven by their growing popularity. It seems obvious that use of a device that helps smokers to quit conventional tobacco use should be encouraged, and therefore intuitive that regulation should be minimised. However, like all good debates, there are many grey areas; long-term safety data are required, and there have been signs in recent weeks that safety should be a primary consideration.

Earlier this month, eight US senators asked the Food and Drug Administration (FDA) to assess the potential cancer risk associated with the high-powered tank systems of e-cigarettes, following media reports of two studies that will be reported in Nicotine and Tobacco Research describing the release of formaldehyde (a known carcinogen) in the vapour. Tank systems are larger devices than traditional e-cigarettes that can hold more nicotine and have variable voltages. The devices can be modified by retailers and users. According to a report in The New York Times, the studies show that these systems can allow high temperatures to be reached that result in the release of toxins.

Additional safety concerns were raised in April by the US Centres for Disease Control and Prevention, which noted that the number of documented exposures from e-cigarettes reported to US poison centres had increased from one per month in September, 2010, to 215 per month in February, 2014, with 51·1% of those affected aged 0–5 years; by contrast, no increase was seen over the same time period in the number of exposures to conventional tobacco. Exposures differed between the two products, with ingestion exposures being more common for tobacco (97·8% vs 68·9%) whereas inhalation (2·0% vs 16·8%) and eye (0·1% vs 8·5%) and skin exposures (0·1% vs 5·9%)—resulting in vomiting, nausea, and eye irritation—were more common for e-cigarettes than for conventional cigarettes. Worryingly, exposures from e-cigarettes accounted for 41·7% of the combined monthly e-cigarette and cigarette exposure reports to the poison centres in the latest data. The Guardian newspaper, using data from the National Poisons Information Service, has also reported a similar increase in the number of poisonings from e-cigarettes in the UK. In view of the results of a recent survey by the UK Action on Smoking and Health group, which showed that e-cigarette use in the UK has tripled from 700 000 in 2012 to a staggering 2·1 million in 2014, the number of poisonings can be expected to increase. The survey authors also noted that the proportion of smokers and ex-smokers who had ever tried e-cigarettes rose from 8·2% in 2010 to 51·7% in 2014.

Preclinical data reported at the 2014 American Thoracic Society meeting in San Diego (CA, USA, May 16–21; abstract 57341) also suggests e-cigarettes might not be as benign in terms of toxicity as manufacturers suggest. Researchers showed that the virulence of drug-resistant bacteria was increased by vapours from e-cigarettes, possibly through changes in pH, and also that the ability of cells to destroy bacteria was impaired; although in parallel experiments the bacteria were even more virulent in the presence of tobacco smoke. Nevertheless, the growing number of reports emphasising safety concerns with e-cigarettes means that this issue needs careful consideration.

The explosion in the use of e-cigarettes has meant regulatory authorities have struggled to keep pace with technological developments. On Apr 24, 2014, the FDA announced that it will now regulate e-cigarettes and has proposed minimum age requirements for their sale, inclusion of health warning labels, and the reporting of the ingredients of the product. As previously discussed in The Lancet Respiratory Medicine, there has been a worrying mirroring of big tobacco tactics in the marketing of e-cigarettes towards young people, so it is reassuring that the FDA is taking some steps to protect this vulnerable group, although there will probably be a delay before these measures are fully implemented. Notably, several US cities have implemented indoor bans this year. These bans should prevent a return to the normalisation of smoking by stopping the use of e-cigarettes in public indoor spaces, as well as ensuring that the precautionary principle is applied until more evidence on second-hand exposure to vapours is available.

Many would agree that, used appropriately, the e-cigarette has a valuable part to play in smoking cessation, but because the long-term safety of e-cigarettes is unclear, and the effects of second-hand exposure to vapours unknown, we need to proceed cautiously, working hand-in-hand with regulators, to ensure that users and the general public are protected from harm.

[GradmaP]

I've recently changed from an e cigarette to a Nicorette inhaler as I was concerned about the safety of the vapour with COPD, the Nicorette inhalers have been regulated and are available on prescription. I think these are a better option, my carbon monoxide reading yesterday was normal so I will continue with the safe ones as I love my nicotine.......