High IgE

I have a very high IgE (last blood test I think it was over 2000) and this was on 5mg of Levocertizine twice a day. I am wondering What can be done to lower IgE? and could this be making my asthma worse?

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If you google 'ige, asthma, vitamin d' you will find loads of articles and research linking higher ige levels and asthma with Vitamin D deficiency.

So might be something to consider.

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Forgarty (Lancet, 2000) shows dietary vitamin E ""were associated with lower serum IgE concentrations and a lower frequency of allergen sensitisation"" (ncbi.nlm.nih.gov/pubmed/110...

Magnesium has been shown to have similar effects but I don't have a citation to hand.

You may have also heard of Omalizumab (Xolair) in the press. This monoclonal anti-body is an IgE inhibitor indicated in atopic asthma but is very expensive. It also requires that you have confirmed allergy to perennial aero-allergen. Your allergen specific IgE and skin prick test positive results as opposed to total IgE maybe more relevant.

You may wish to expore allergen desensitisation/immunotherapy subject to your physician's advice rather than trying to lower your IgE levels as a whole. Numerous studies show it be highly effective in reducing allergy related asthma. You should also keep an eye on Cytos Biotech that have developed a promising ""allergy vaccine"" which modulates the immune response without introducing an allergen. This may not be too far away now they are starting phase 3 trials.

Good luck

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I dont have any allergies as such that they can find so cant have de-sensisation and my IgE is too high for Xiolair unfortunalty... so going sub-cut

I have been taking magnesuim supplements for a while but dosnt seem to be helping!

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high IgE

Having a high IgE means you're atopic or in other words you have allergies.

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veggiebab,

not sure why you've answered an old topic and said a high IgE means atopy or allergies after bizkid said none were found on tests.