How long should it take for a prescription OA to kick in to ease the pain? I've been on diclofenac 500 Mg 2x a day for a solid month and I'm not seeing much difference if any from when I started taking it. This is the 5th one I've tried in over a year and not one of them has helped me. Should I stop all media and just deal with the pain. My hand hurt pretty bad this past Wednesday and other areas of my body as, well. I'm beginning to even think if there's anything that will ease my pain. Not sure what to do next about this.