Weird follow up

[2learn]

Thanks for everyone who replied to my weird post, however I obviously wasn't clear in it and everyone kind of missed the point.

The point I was trying to make was that although I have reduced my bisoprolol dose from 5mg to 2.5 my BP has gone down and my tiredness has increased. Thats what I thought was weird as its the opposite to what I expected. The idea of reducing bisoprolol was to improve tiredness and consultant thought my BP may go up. I wondered if this was a side effect of coming off Bis and whether anyone else had experienced anything similar.

So the comments about needing an ablation, I had one in March 2022, its still working, and getting used to Bis, I have taken it since 2014 when I first went into AF. I usually stop it in one clean go after say a cardioversion or ablation, without any withdrawal probs.

So thanks anyway for your care and sorry for being unclear.

[10gingercats]

in a discussion recently with my doc. he said that Bisoprolol does not affect blood pressure but Furosimide certainly does.I understand your queries were not about furosimide but they formed part of my chat and so brought forth the info. about Bisoprolol.

[KMRobbo in reply to 10gingercats]

But Bisoprolol is a blood pressure reducing drug??.nhs.uk/medicines/bisoprolol...

[Ppiman in reply to KMRobbo]

I read somewhere that betablockers have a quite small lowering effect on BP, but a much greater effect on heart rate (as I find). I did read somewhere that bisoprolol's dosage effect is non-linear, meaning that halving the dose doesn't necessarily halve the effect, although why you feel worse on the lower dose is a mystery. One thought I had was that the higher heart rate you have now with the lower bisoprolol dose might be somehow. and perversely, less efficient at pumping oxygenated blood around than the lower heart rate you had before. Have you taken your blood oxygen levels, for instance, to check all is well there?

Steve

[2learn in reply to Ppiman]

I never said I had a higher heart rate

[Ppiman in reply to 2learn]

AsI understand it, bisoprolol lowers the heart rate quite significantly, although apparently not in a linear way dose-wise; and yet it lowers the blood pressure just a little. I assumed if you’d halved the dose, your heart rate would go up - but maybe not.

Steve

[KMRobbo in reply to Ppiman]

There is also the sensitivity of the person to the drug.1.25mg Bisoprol put me to sleep in 45 minutes of taking it. My normal hr of 70 dropped to low 40s I did not have a BP MONITOR at that time so could not tell you how much that reduced. After trying atenolol 25mg with similar but not as bad effects my GP decided I could not tolerate beta blockers and moved me to Calcium Channel blockers.

[Ppiman in reply to KMRobbo]

Crikey - that was a worry for you. I’ve read that some people can’t tolerate them.

Steve

[KMRobbo in reply to Ppiman]

I dont know, but suspect if the consultant cardiologist had given me 5mg like I have read some on HUL have been given I may never have woke up after the first pill!

[Ppiman in reply to KMRobbo]

I think 5mg is the standard dose given to stop AF (well that’s what I was given). I’ve never heard of anyone falling asleep after bisoprolol so maybe you have a very specific reaction to it.

Steve

[Treschere]

Are you taking Amalopadine?

[2learn]

thanks never thought of that

[Tomred]

hi 2learn , you say at the end of your post that you usually stop clean without out any withdrawal effects, maybe the tiredness increase is a withdrawal effect.