Changing dose of Edoxaban

[quanglewangle]

Hello

I am confused and wonder if anyone else has been told by their GP-Pharmacist to reduce their Edoxaban dosage (60 down to 30mg per day). Looking up Edoxaban tells me that I should be on the higher dose because I am over 75, weigh 75kg, have Atrial Fibrillation and have had a TIA. The change was predicated on my ‘Creatin Clearance’. My RBC and Haemacrit are a bit low and my MCV and MCH are high. .

I know what these figures from my FBC are but do not really understand the implications. Has anyone got a clue? Should I ask the Haematologist for his opinion on the change?

[quanglewangle]

P S - I have had no issue with Edoxaban - no bleeds, nosebleeds or bruising ..... so why the reduction and I assume increased risk of stroke?

[Hidden]

I’m not medically trained so please check this with your Doctor. Edoxaban (and other anticoagulants other than Warfarin) depend on the kidney function for removing unwanted chemicals from your system. It looks like your kidney function may have reduced, probably due to age, therefore they have asked you to reduce your dose which is quite common. As I understand it, NOAC’s such as Edoxaban do not cause harm to the kidneys but this is the reason why folks who take NOAC’s should have blood tests every six months to check their kidney function……

[Fullofheart]

I don't know in your case but I'm on reduced dose of 30 my because I'm also on dronedarone. As I understand it the reduced rate is recommended in combination with some other drugs. I had the same previously when on amiodarone.