Interesting study in the European Society of Cardiology confirming that high blood pressure causes atrial fibrillation:
escardio.org/The-ESC/Press-...
Previous studies have only shown an association between high blood pressure and developing atrial fibrillation....
To investigate whether blood pressure has a direct impact on the risk of atrial fibrillation, the researchers conducted a naturally randomised controlled trial – called Mendelian randomisation. They used data from the largest genome-wide association study (GWAS) on blood pressure and atrial fibrillation which included more than one million individuals of European ancestry – of which 60,620 had atrial fibrillation and 970,216 did not.
The first step was to identify 894 genetic variants associated with blood pressure. Next, the researchers analysed which of those variants play a role in atrial fibrillation. To conduct the naturally randomised controlled trial, the 894 genetic variants were randomly allocated to all participants at conception, giving each individual a blood pressure level. The investigators then analysed the association between blood pressure and atrial fibrillation.
Elevated blood pressure was associated with an increased risk of atrial fibrillation. Specifically, 1 mmHg rises in systolic blood pressure, diastolic blood pressure and pulse pressure were associated with 1.8%, 2.6% and 1.4% relative increases in the risk of atrial fibrillation, respectively"
“Our findings confirm the hypothesis that atrial fibrillation is preventable. This indicates that strict blood pressure control could be an effective strategy to stop atrial fibrillation and its complications, which include stroke, heart failure, dementia, and depression.”