New medication : Interesting new... - Atrial Fibrillati...

Atrial Fibrillation Support

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New medication

sportscoach profile image
11 Replies

Interesting new developments in the treatment for AF...

labiotech.eu/acesion-pharma...

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sportscoach profile image
sportscoach
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11 Replies
davythom profile image
davythom

Thank you for the post interesting.

Finvola profile image
Finvola

Thank you for posting this - good to read of any development in drug therapy.

dedeottie profile image
dedeottie

Interesting and hopeful. Thank you.

jeanjeannie50 profile image
jeanjeannie50

Interesting , thank you for posting.

doodle68 profile image
doodle68

Hi SC :-) it's good to know new drugs are in the pipeline.

I think in years to come they will develop a drug for AF that will dispense with ablation and anything else that is on offer at the moment .

With an aging population and more people developing AF it will become increasingly cost effective for drug companies to find a suitable drug.

Peddling profile image
Peddling

Very encouraging news. Thank you for posting.

doodle68 profile image
doodle68

Hi Sportscoach :-) I have found a little more information about this drug if you will permit me to add it to your thread . Below is a quote which adds a little weight to the clinical study, more details about AP30663 in the link..

novoholdings.dk/globalasset...

..................................................................................................................................................................

''Acesion has appointed a group of scientific advisors comprising world-renowned experts in atrial fibrillation, including:

 Prof John Camm, Professor of Clinical Cardiology at St George's Hospital Medical School, University of London and Professor of Cardiology at Imperial College London

 Dr Jeremy Ruskin, Professor of Medicine at Harvard Medical School and Founder and Director Emeritus of the Cardiac Arrhythmia Service at Massachusetts General Hospital

 Prof Dobromir Dobrev, Professor at the Institute of Pharmacology at the Universitätsklinikum

Essen, Germany

 Bob Humphries, pharmacologist with 30+ years of pharma experience (Fisons, Astra and

AstraZeneca) as scientific and cross-functional project team leader''

..................................................................................................................................................................

sportscoach profile image
sportscoach in reply todoodle68

No problem at all doodle68 the more information the better.

Thanks for that sportscoach

The combination of long term efficacy, patient tolerance and safety, of rhythm control meds has proved elusive in AF.

In contrast, all three have steadily improved in the hands of the electrophysiologists.

Does this new drug change that dynamic?

fnurd profile image
fnurd

Interesting. We do however need to remember that even if the drug proves to be highly effective and safe, the regulatory process will mean that it will not appear on the market for many years. And then there is NICE ...

Jhcoop55 profile image
Jhcoop55

As noted elsewhere, this is an early stage clinical trial that hasn’t been tested yet in humans. Positive Animal data, while interesting, is merely a data point that allows for further testing in humans. Since AFIB impacts a relatively large population, the pivotal phase 3 clinical trials (which confirm the earlier, smaller and hopefully positive early stage trials) will require lots of patients and time. Often, it can take 7 plus years or so to work its way through lengthy trials and eventual regulatory approvals. That being said, if these trials show early stage positive results, that may spur further research by other companies in the field. Kind of surprising that there isn’t more research going on given the incidence of this nefarious condition.

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