Hi, is it normal to feel tired whilst taking Beta blockers? Bisoprolol. Ive been taking 2 per day as prescribed and now my specialist says I can try 1.5 per day and if my heart dosnt start banging about try 1. Ive felt a difference in walking up hill on the 1.5 so I'm trying 1 per day from now on. My heart rate has gone from 50 to 55/57 . By cutting the b.blockers down am I opening myself up to more risk of stroke? Or is it the Pradaxa I'm using taking care of that?