On holiday in Spain with a group of friends for a walking holiday. One of the party, who has persistent AF and like me is on Apixaban had a major bleed from a burst varicose vein. Lost a lot of blood whilst waiting for ambulance but bleeding was easily stopped in hospital with compression. She was discharged the same evening and after a good nights rest is back to normal. I don't think that any external bleed would cause a problem. Internal might be another matter but pretty unlikely.