Help After Spinal Radiation

[Sailameme]

Hi Guys

My husband has many more lymph node mets and spinal mets and 4 fractured vetebra recently observed on CT scan and bone scan.

Received one session of radiation, pain manageable , mobility limited. The radiation was a large dose, he is totally exhausted after 4 months of Docetaxal (which failed) and then the spine mets being radiated all in the last 4 months

The Oncologist says he has exhausted all treatments and no clinical trials will help , he is castrate resistant, with last psa of 91 as of 2 months ago whilst on doxcetaxal. Now told and diagnosed with Chemo Refractory Disease, negative Braca 1or 2.and it's just a matter of time??..

I am totally devasted but pleae help, is there any other treatments, anything that anyone can help me with, we are considering a second opinion? In Vancouver Canada attending BC Cancer Agency Vancouver.

Thanks so much

Knittinque xx

[Sailameme]

Sorry Psa 911 (not 91)

[Tall_Allen]

Cabazitaxel often works when docetaxel fails.

[Sailameme in reply to Tall_Allen]

Than you TA always can rely on you for prompt feedback. The Oncologist said he is Castrate Resistant and has Chemo Refractory Disease, l take that as no chemo will work so my question is is there anything else

He has done at 2014 diagnosis, Adt 3 years Radiation to Prostate, watch and wait 5 years, psa rose to 54 back on Adt again failed Enzalutimide failed, Docetaxal failed. Radiation on spine, worked and lessened pain, mobility limited at the moment. Working on that. But what is there left to take to slow the progression of the cancer on lymph nodes or wherever else it might travel.

Onco said nothing will work no clinical trials???? I read on hear all the time Men who have more mets on bones than my husband and they are still chugiing along on some other form of therapy. Help please

[Tall_Allen in reply to Sailameme]

How would he know if he is cabazitaxel- refractory if he has only had docetaxel? Cabazitaxel was specifically indicated for docetaxel-refractory PCa. In fact, combination with carboplatin seems to work particularly well.

[Sailameme]

Sorry forgot to mention Orchiectomy was in 2023 as well

[j-o-h-n]

Greetings Sailameme, Would you please be kind enough to update your dear husbands bio. (include his age) Thank you and give him OUR regards.

Good Luck, Good Health and Good Humor.

j-o-h-n