My takes from the webinar with Dr Sartor and Shore...and others...

[Maxone73]

Actually there were many more doctors but I forgot the names (the webinar has been recorder by Prostate Cancer Foundation, so I suppose there will be a link to watch it).

1 - there are many options and more will come soon

2 - they always push for curative even if stage 4 with mets

3 - darolutamide is quite darn cool compared to the results of even only 3-4 years ago with other ARSis

4 - from doctor IdontRemember famous endocrinologist that is also a prostate cancer patient: take vitamin D, and use a thing called Külkuf for hot flashes, it's a device that seems to work

5 - ALWAYS have a genetic test

6 - Vitamin D for the bones (from dr Saad) and Bone Protective Agents are great also to prolong OS, especially with Radium

7 - Clinical trials are becoming more widespread and secure

8 - Thanks Prostate Cancer Foundation for helping research

That's basically it (I intentionally did not pay attention to the parts talking about when the patients start refusing to undergo another therapy and so on...)

[MoonRocket]

#5 genetic testing...Is this both germline and somatic? Is the latter advised for high risk patients vs low to intermediate risk patients?

Thanks Max

[Maxone73 in reply to MoonRocket]

From what I understood: germline is good at the beginning of course, then you must work on somatic, especially when the current treatment starts failing, because there could be a mutation that is actionable. Since the majority of cancers are somatic, at some point they recommend to have a somatic test. I should watch it again but if I remember correctly, recommended for mid and high risk, if the MO is not ok with it talk directly to a genetic counselor. I have also asked a direct question about ATM but I got no answer (and I was one of the few who did not get an answer!!!)

[Tinkudi]

thanks Maxone 😊

Do you have any more info on Kulkuf ?

Any more details of why darolutamide is better than other ARSIs ?

[SViking in reply to Tinkudi]

Yes I’d like to know more about that also

[Maxone73 in reply to Tinkudi]

Kulkuf is a device for hot flashes, a wrist band that gets cold instantaneously when needed, look for kulkuf hot flashes on google. They did not say that darolutamide is better, but that aranote and ARASENS studies continue to impress the searchers

[SViking]

do you have a link to this webinar?

[Maxone73 in reply to SViking]

not yet, they had not published it when I last checked

[pe43]

The endocrinologist you refer to is Michael Holick. He's known for advocating high doses of vitamin D, and apparently takes 6,000 IU a day. See this 2024 article in Scientific American:

scientificamerican.com/arti...

[Maxone73 in reply to pe43]

Yes, thanks! I remembered just that his names started with an H

[podsart in reply to pe43]

Make sure take tests to monitor levels as this is an oil vitamin

[dhccpa]

Thanks

[Yzinger]

thanks for the post Maxone. I really liked #1, 2, and 3.