CT Scan looks good but PSA going up ?

[God_Loves_Me]

MO told me CT Scan and Bone scan looks good but my PSA increase 2.18 > 3.38 >4.60

Anyone know the reason when PSA increase but scan looks good ?

I have PET CT PSMA Scan next week

[NanoMRI]

I had a clear Ga 68 PSMA PET but the 'better' Ferrotran nanoparticle MRI (sadly still very limited availability in Europe) successfully identified cancerous pelvic lymph nodes - confirmed by surgery. There can be multiple reasons why scans miss mets, including size and contrast agent uptake. Some radiologists suggest trying differing contrast agents in hopes one will work. Hope this helps. All the best!

[6357axbz]

you should have a psma scan

[MoonRocket]

Your MO is watching the radiographic progression. I don't thinking PSA is a good marker to watch real close.

[Tall_Allen]

Bone scans aren't very sensitive.

[Ian99]

I had this scenario for 2 years. MO focuses on scan compares and lack of radiographic progression and tends to ignore a rising PSA which is viewed as just a biomarker. Personally I was concerned about the level of granularity of those scans but that is SOC.

[fast_eddie]

Why hasn't your MO prescribed more sensitive scans? I've had Axumin and Pylarify scans. They both came back negative for my slowly increasing PSA. Prostate is still intact. I am 74.