Australia speeding up on cancer vaccines

[Maxone73]

not strictly PCa related but it illustrates the trends!

news-medical.net/news/20240...

[Maxone73]

but also in NJ some companies are working

biopharminternational.com/v...

[KocoPr in reply to Maxone73]

That’s great! They wouldn’t invest this much unless it had hi hopes of success

BeiGene, an oncology company, announced on July 23, 2024 that it has opened a new biologics manufacturing facility at the Princeton West Innovation Campus in Hopewell, NJ. The facility represents the company’s flagship facility in the United States and also houses a clinical R&D center. The company invested $800 million into the site to expand its integrated manufacturing and R&D footprint in the US.

BeiGene has more than 30 molecules at clinical- or commercial-stage development. The new 42-acre facility gives the company flexibility to scale production of these drug candidates presently and in the future to meet cancer patient needs. The Hopewell site comprises approximately 400,000 ft2 of space dedicated to commercial-stage biologic manufacturing capacity and includes additional space to expand over time as BeiGene’s pipeline matures.

The facility strengthens BeiGene’s late-stage research and clinical development capabilities. The company’s oncology pipeline addresses 80% of global cancers using modalities such as targeted degraders and antibody drug conjugates as well as monoclonal antibodies and traditional small molecules. The new facility enables the company to produce at scale, which reduces costs and ensures supply chain resiliency. The company aims to avoid global disruptions, protect capacity, and rapidly adapt to the latest innovative modalities, according to a company press release.

[inter100]

These vaccines that are being produced are quite special.Normally a vaccine only prevents disease.These novel vaccines are able to prevent and treat the disease.I think that's quite a unique action for a vaccine .Here in UK the NHS (National Health Service) , a free to all citizens medical treatment service, is aggressively trialing several cancer vaccines which are showing great promise and efficacy.I hope the trials are as successful as they seem to be in these early stages.

[Bkraus1 in reply to inter100]

I live in the US and have not heard about this for prostate cancer. Where can I learn more about this?

[Maxone73 in reply to inter100]

I have never heard about a preventive vaccine for cancer. Also because most vaccine are autologous, so they need the subject's cancer cells to develop the vaccine which is tailored on the patient. But I might have missed it.

[Maxone73 in reply to inter100]

I went to check and I confirm, no preventive vaccine exists for cancer at the moment

[inter100 in reply to Maxone73]

There is the HPV vaccine

[Maxone73 in reply to inter100]

It acts on a virus that may cause cancer, not on the cancer, in fact HPV is not the only cause of cervical cancer…

[FrostGyre]

Quite worrying that you think vaccines prevent disease!

[FrostGyre]

More insanity. Clearly they haven't learned anything from the covid debacle.

[j-o-h-n]

From A and i

Preventive vaccines for cancer are a fascinating area of research and development. They aim to prevent cancer from developing in the first place, rather than treating it after it has already occurred. Here are some key points about this type of vaccine:

Existing Preventive Cancer Vaccines:

HPV Vaccine: One of the most well-known preventive cancer vaccines is the human papillomavirus (HPV) vaccine. HPV is linked to several cancers, including cervical, anal, and oropharyngeal cancers. Vaccines like Gardasil and Cervarix protect against the most cancer-causing strains of HPV.

Hepatitis B Vaccine: The hepatitis B virus (HBV) can lead to liver cancer. The hepatitis B vaccine helps prevent HBV infection and, consequently, reduces the risk of liver cancer.

Research and Development:

Cancer Antigen Vaccines: These vaccines target specific proteins or antigens expressed by cancer cells. The idea is to train the immune system to recognize and attack these proteins before cancer can develop. This approach is still largely experimental but holds promise.

Personalized Cancer Vaccines: Researchers are working on vaccines tailored to the individual’s specific cancer mutations. These vaccines aim to provoke a strong immune response against the unique markers of a person’s cancer.

Challenges and Future Directions:

Complexity of Cancer: Unlike infectious diseases, cancer can arise from a variety of genetic mutations and environmental factors. This makes developing universal preventive vaccines challenging.

Immune System Response: Ensuring that the vaccine generates a strong and lasting immune response is crucial. Researchers are exploring various ways to enhance this response.

Current Status: While preventive vaccines for certain cancers are already in use, the field is rapidly evolving. Continued research is expected to bring more vaccines to the forefront, potentially broadening the scope of cancer prevention in the future.

Preventive cancer vaccines represent a promising frontier in oncology, with the potential to significantly reduce cancer incidence and impact.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Maxone73 in reply to j-o-h-n]

And yet it talked about two viruses and not cancers directly 😃😃 not saying that in the future it won’t be possible, but at the moment preventive cancer vaccines are not available

[Brysonal]

I had the OVM-200 vaccine at phase 1 clinical trial.

It just won a prize for its technology but no phase 2 that I’m aware of yet.

globaltechip.com/2024/06/1428/

[Maxone73 in reply to Brysonal]

yes I am following it.

oxfordvacmedix.com/completi...

oxfordvacmedix.com/major-mi...

[Seasid]

Sunday, 28 July 2024

4:56 PM

Q. Is hyperthermia in cancer treatment act as a vaccination?

A. Hyperthermia in cancer treatment does not act as a vaccination. Hyperthermia involves heating body tissues to damage and kill cancer cells or to make them more susceptible to other treatments like radiation therapy and chemotherapy. It works by increasing the temperature of the tumor cells, which can enhance the effects of these treatments and potentially improve their outcomes.In contrast, a vaccination works by stimulating the body's immune system to recognize and fight specific pathogens or disease-causing agents. While hyperthermia can sometimes stimulate an immune response against cancer cells, it does not create the same lasting immunity that a vaccine does.However, some research is exploring the use of hyperthermia in combination with immunotherapies to boost the immune system's response to cancer, potentially leading to more effective treatments.

Q. Chemotherapy and radiation therapy can release antigen and stimulate the immune system against cancer

A. Yes, chemotherapy and radiation therapy can release antigens and stimulate the immune system against cancer. This process is known as immunogenic cell death. When cancer cells are killed by these treatments, they can release tumor antigens and other molecules that signal the immune system to recognize and attack the remaining cancer cells. Here’s how it works:1. **Antigen Release**: As cancer cells die due to chemotherapy or radiation, they release antigens specific to the tumor.2. **Immune Activation**: These antigens are taken up by antigen-presenting cells, like dendritic cells, which then present them to T-cells.3. **T-cell Response**: The T-cells become activated and can target and destroy remaining cancer cells that express the same antigens.This process can enhance the body's natural immune response to cancer, potentially leading to better outcomes. Combining traditional therapies with immunotherapies is an area of active research, aiming to improve the effectiveness of cancer treatments by leveraging this immune activation.

Q. Can hyperthermia effect the cancer to release antigen?

A. Yes, hyperthermia can affect cancer cells in a way that promotes the release of antigens and stimulates an immune response. The heat stress induced by hyperthermia can cause cancer cells to undergo a form of cell death that is more immunogenic. Here’s how this process works:1. **Heat Stress**: Hyperthermia exposes cancer cells to elevated temperatures, causing them to become stressed and eventually die.2. **Antigen Release**: As cancer cells die from heat stress, they release tumor antigens into the surrounding tissue.3. **Immune System Activation**: These antigens can be taken up by dendritic cells and other antigen-presenting cells, which then migrate to lymph nodes and present the antigens to T-cells.4. **T-cell Response**: The activated T-cells can then seek out and destroy other cancer cells that express the same antigens.In addition to antigen release, hyperthermia can increase the permeability of the tumor vasculature, enhance the infiltration of immune cells into the tumor, and improve the effectiveness of other treatments such as radiation and chemotherapy. This makes hyperthermia a promising adjuvant therapy that can potentially boost the overall immune response against cancer.

[Fuzzman77]

Sounds the same as what I had back in early 2018. They made them via Mrna and I had to travel to India to have it done. Then, it was through Baylor, but I had to do it outside the United States to have it done. It's still here, but I am very lucky for sure. It is now being offered through Cancun, and I have visited there a few years ago. Luckily, I am still going, and seem to have gotten over Long COVID. It took three years to get over it, but I am now doing much better. COVID was pretty bad. I had Lamda from Peru. I had a stroke etc, had to learn how to walk again which took awhile, and was in the hospital for 35 days. The one Baylor guy now lives in Cancun, and his name is Matt. He'd be happy to talk to anyone that is interested. He does know what he is talking about down there. He can help you with any questions you may have.