Intraductal Carcinoma and Cribriform Glands Present

[ToryCarlisle]

Hi!

Am wondering if anyone can speak to intraductal carcinoma and cribriform glands. My husband just had a prostatectomy several weeks ago. Follow up appt with surgeon is next week. Overall the pathology report seems good! They downgraded his Gleason score from a 9 to a 7 (4+3), margins were clean, and lymph nodes negative. But they did note intraductal carcinoma and cribriform glands. I've tried to do some reading on both, but would like to hear from anyone with similar results.

Am hopeful since the prostate has been removed he'll be good to go!

Thanks!

[Melzer2169]

my husband also had this noted on his Pathology post RP. although his margins were positive but no nodes. We had Genetic/genomic testing done and learned that he has somatic TP53BP1 and ATM mutations ...its all overwhelming but what I have learned is that these all mean its more aggressive and further treatment may become necessary. For now his PSA is below .05 but I still worry because his PSA was never high. Not sure the worry ever goes away, but for now we are hoping its gone. Sorry not of more help....

[ToryCarlisle in reply to Melzer2169]

Thanks so much for your response. Yes, my husband's PSA was never high either. I've read something about some types of prostate cancer not throwing off PSA like others and was wondering how they test for recurrance if that's the case. I'm glad to hear your husband is doing well, and I hope he has continued good health!

[Melzer2169 in reply to ToryCarlisle]

Best wishes for you as well. I've clicked the "following" on your profile. Maybe we can keep each other informed if we learn anything new about this "intraductal". hopefully new research will bring more help, seems there is a lot going on so very hopeful for the future!

[Bcgkelly]

I was told that my cancer was intraductal as well. I had RP & lymph node removal five years ago. The only thing I was able to find out about intraductal is that it’s rare and considered aggressive. However, my cancer appears to be slow growing. PSA. is increasing slowly. I’m not on any treatment at the moment.

[ToryCarlisle in reply to Bcgkelly]

Thanks for sharing! And so glad to hear that you're doing pretty well and that your PSA is increasing slowly. I hope you continue to feel good.

[FMOH_N]

I have both on my histology report. Had RALP about two months ago. Unfortunately, these findings have adverse prognostic with respect to BCR, much shorter time to BCR, metastases and survival.

I am wondering what shall be done now, in order to increase the time to BCR, and improve outcomes with respect to occurrence of metastases and have better survival. Is it possible that you can hear with your MO what is recommended?

Maybe some rounds of chemotherapy, now, will improve the outcome and prevent spread of disease. we know that even if the cancer was confined there is a high chance that some cancer cells have escaped. microscopic cancer cells at this stage can not be detected by PSMA PET or other scans.

[KenJamgo]

Hi Tory, New here and just getting started after having Rad P. 4.4.24 and seeking others in the same boat. How is your husband doing now that it's been roughly a year since your last post? Hopefully going well? Did your husband have Peri neural invasion? and extra prostatic extension in his diagnosis as well? I seen you posted also addressing the complexity of Intraductal PC now registering concretely via PSA labs. This seems to be the big challenge as it's like playing a football or basketball game without a time clock; we're in the action but not fully clear as to what the parameters are. Did you find anything that helps keep your husband updated on his condition more precisely? Hope to hear good news from your next update. Thanks Tory