Anyone aware of Capivasertib (truqap ) ? Approved by FDA. Am considering a trial involving Docetaxel and Capivasertib. Am interested in any feedback on this drug, which has not yet been approved here. Thanks.
Does anyone know about Capivasertib - Advanced Prostate...
Does anyone know about Capivasertib
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The combination was tested in this trial and extended overall survival: pubmed.ncbi.nlm.nih.gov/356...
Here's what I have:
sciencedirect.com/science/a...
It is thought to be particularly effective in men who have a genomic issue called "PTEN loss," and there are a few of trials for that:
clinicaltrials.gov/study/NC...
clinicaltrials.gov/study/NC...
Those are for men who are still hormone-sensitive, but there are some trials for men with PTEN-loss who are castration-resistant using biosimilar drugs:
clinicaltrials.gov/study/NC...
classic.clinicaltrials.gov/...
A biosimilar drug, ipatasertib, had mixed results in a trial to men who are castration-resistant with PTEN-loss:
thelancet.com/journals/lanc...
However, it was quite toxic:
clinical-genitourinary-canc...
Capivasertib may be less toxic and has been FDA-approved for women with some types of breat cancer.
On Cousin Google:
Phosphatidylinositol-3-kinase (PI3K)/Akt (PI3K/AKT) pathway is one of the most commonly altered pathways in breast cancer.•
Capivasertib (AZD5363) is a highly potent Akt kinase inhibitor with activity against the three isoforms AKT1, AKT2, and AKT3.•
Preclinical studies demonstrated efficacy of capivasertib either alone or in combination with anti-HER2 agents, chemotherapy and endocrine treatment.•
Dose-limiting toxicities include hyperglycemia (20–24%), diarrhea (14–17%) and maculopapular rash (11–16%).•
Capivasertib increased susceptibility to paclitaxel (PAKT, BEECH), fulvestrant (NCT01226316, FAKTION) or Olaparib (ComPAKT).
Good Luck, Good Health and Good Humor.
j-o-h-n